{"id":"W4366606979","doi":"10.1016/j.cell.2023.04.024","title":"ESCRT recruitment to SARS-CoV-2 spike induces virus-like particles that improve mRNA vaccines","year":2023,"lang":"en","type":"article","venue":"Cell","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"Houston Methodist Research Institute; National Institutes of Health; California Institute of Technology; Fast Grants; George Mason University; Bill and Melinda Gates Foundation","keywords":"Virology; Biology; Antibody; Messenger RNA; Neutralizing antibody; Virus; Spike (software development); Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Spike Protein; Coronavirus disease 2019 (COVID-19); Gene; Immunology; Genetics; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001241796,0.0002895311,0.0001759107,0.00009526863,0.00008522972,0.0002632712,0.0001083684,0.0002484778,0.001554967],"category_scores_gemma":[0.0001225331,0.0001078577,0.0001699523,0.00006778305,0.0001449888,0.0001587102,0.000235184,0.0004311539,0.0006383239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002724979,"about_ca_system_score_gemma":0.0001497757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002083979,"about_ca_topic_score_gemma":0.0005393287,"domain_scores_codex":[0.9998817,0.00001723213,0.000008409618,0.00002845043,0.00003145348,0.00003268565],"domain_scores_gemma":[0.9999492,0.000009613082,0.00001243283,0.000006354429,0.000009212652,0.00001318347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001914248,0.00001371262,0.00006890539,0.00000856727,0.00000122745,0.0000106129,0.000004654923,0.00005764723,0.9990231,0.00004483016,0.00002812839,0.0007194679],"study_design_scores_gemma":[0.00001166566,0.0002823463,0.001219794,0.000002332371,0.000004817176,0.00006209801,0.00001022054,0.0009550602,0.9956822,0.00002187849,0.001745655,0.000001818358],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892619,0.0005592355,0.007013826,0.00009761246,0.00004685498,0.0000443417,0.0001816923,0.0001258414,0.002668757],"genre_scores_gemma":[0.9905634,0.0002532543,0.005247103,0.00009354212,0.00001564601,0.00003006515,0.0003891445,0.00003170236,0.00337613],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001554967,"threshold_uncertainty_score":0.005201876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1529385633334621,"score_gpt":0.384678422202924,"score_spread":0.2317398588694619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}