{"id":"W4366606979","doi":"10.1016/j.cell.2023.04.024","title":"ESCRT recruitment to SARS-CoV-2 spike induces virus-like particles that improve mRNA vaccines","year":2023,"lang":"en","type":"article","venue":"Cell","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"Houston Methodist Research Institute; National Institutes of Health; California Institute of Technology; Fast Grants; George Mason University; Bill and Melinda Gates Foundation","keywords":"Virology; Biology; Antibody; Messenger RNA; Neutralizing antibody; Virus; Spike (software development); Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Spike Protein; Coronavirus disease 2019 (COVID-19); Gene; Immunology; Genetics; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004749017,0.000271703,0.0003816764,0.0003107439,0.0001220165,0.0000864154,0.0003062386,0.0001438138,0.00002998401],"category_scores_gemma":[0.0001200724,0.0002218851,0.0001517951,0.0008122125,0.00004787026,0.0001219535,0.0002751744,0.0002859417,0.003849405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001324838,"about_ca_system_score_gemma":0.000193005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004301737,"about_ca_topic_score_gemma":0.0001492581,"domain_scores_codex":[0.9976764,0.00005922298,0.0003116915,0.0005854707,0.000598472,0.0007687296],"domain_scores_gemma":[0.9988932,0.0001354126,0.00006802366,0.0006763106,0.0001170266,0.0001100399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002347299,0.0001891555,0.007212459,0.0001230251,0.00004130435,0.0001791079,0.0006647281,3.3938e-7,0.9572012,0.00001223358,0.02107296,0.01306873],"study_design_scores_gemma":[0.0009411664,0.000355313,0.003636803,0.00004600036,0.00003633005,0.000005158997,0.0003358781,0.00008200936,0.7159923,0.0001412476,0.2782493,0.0001785058],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911338,0.0003717482,0.00001736511,0.001551813,0.0006253682,0.001298804,0.00001493489,0.0003051079,0.004681036],"genre_scores_gemma":[0.958485,0.00004184427,0.0001648201,0.03955695,0.0004122977,0.0003779502,0.000008338606,0.00006824906,0.0008845325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2571763,"threshold_uncertainty_score":0.9969262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1529385633334621,"score_gpt":0.384678422202924,"score_spread":0.2317398588694619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}