{"id":"W4366609209","doi":"10.1055/s-0043-1768238","title":"Replication Timing Aberration of KIF14 and MDM4/PI3KC2β Alleles and Aneuploidy as Markers of Chromosomal Instability and Poor Treatment Response in Ewing Family Tumor Patients","year":2023,"lang":"en","type":"article","venue":"Global Medical Genetics","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Aneuploidy; Chromosome instability; Replication (statistics); Biology; Genetics; Allele; Genome instability; DNA damage; DNA; Chromosome; Virology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002058906,0.000143659,0.0001996903,0.0006329942,0.0001762746,0.0002513806,0.0001145856,0.0002431253,0.001195568],"category_scores_gemma":[0.0009353029,0.00008740601,0.0001482699,0.00037509,0.0001147822,0.0001862664,0.0001393243,0.0002311558,0.0001102876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001772878,"about_ca_system_score_gemma":0.00008128816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006392447,"about_ca_topic_score_gemma":0.0007840467,"domain_scores_codex":[0.9998672,0.000030008,0.00001678004,0.00003230559,0.0000250687,0.00002868084],"domain_scores_gemma":[0.9995208,0.000121144,0.0002036997,0.00002328297,0.00003952236,0.00009155171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004601562,0.00002284725,0.9942338,0.00000505044,0.00002395353,0.0001734168,0.0000379845,0.00006937256,0.002186345,0.00001109035,0.00004285486,0.002733177],"study_design_scores_gemma":[0.000009488179,0.0001900881,0.9974999,0.000002484587,0.00002391375,0.001111646,0.00006427028,0.0003702346,0.0005381236,0.00003750082,0.0001496441,0.000002904965],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999631,0.0001335823,0.00004525529,0.00001101453,0.000001268911,0.000001941601,0.00005245031,0.000002219392,0.0001212086],"genre_scores_gemma":[0.9998243,0.00001979734,0.00002137251,0.000003574786,0.000001822291,0.000002133263,0.00004922361,5.383589e-7,0.00007727427],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001195568,"threshold_uncertainty_score":0.003999591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01125768566080428,"score_gpt":0.2708924881516434,"score_spread":0.2596348024908391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}