{"id":"W4366609228","doi":"10.1182/blood.2022018719","title":"Genetic subdivisions of follicular lymphoma defined by distinct coding and noncoding mutation patterns","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC; Canada's Michael Smith Genome Sciences Centre; Simon Fraser University","funders":"Michael Smith Health Research BC; Canadian Institutes of Health Research; Canada's Michael Smith Genome Sciences Centre; National Cancer Institute; Genome Canada","keywords":"Somatic hypermutation; Biology; Follicular lymphoma; Diffuse large B-cell lymphoma; Malignancy; Lymphoma; BCL6; Germinal center; Oncology; Genetics; Computational biology; Cancer research; Medicine; B cell; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000383811,0.0001575327,0.0002297624,0.000728848,0.0002138392,0.0004860211,0.0001578602,0.0001990897,0.0006838646],"category_scores_gemma":[0.001321131,0.00007821262,0.0002183711,0.0005200486,0.0002819679,0.0001375009,0.0003247035,0.0001813206,0.00009999266],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003219975,"about_ca_system_score_gemma":0.0002006805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002948614,"about_ca_topic_score_gemma":0.003572411,"domain_scores_codex":[0.9997041,0.000066469,0.0000353345,0.00009941439,0.00005359941,0.00004116113],"domain_scores_gemma":[0.9996686,0.000137544,0.00009570466,0.00004515176,0.00002611417,0.00002697919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004255742,0.00003929948,0.9334862,0.00001979635,0.0001025629,0.000201819,0.0002039761,0.00169438,0.03444744,0.0003009596,0.0001361694,0.02894172],"study_design_scores_gemma":[0.00003552982,0.0001593565,0.9803244,0.00001297765,0.00005500337,0.00147627,0.0003011174,0.01101961,0.004427824,0.001390323,0.0007842074,0.00001332659],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998934,0.00007865675,0.0006427987,0.00001197221,4.816043e-7,0.000007520114,0.0001357146,0.00000983072,0.0001789971],"genre_scores_gemma":[0.9991838,0.00001899242,0.0004262023,0.000008494137,9.107262e-7,0.000006553428,0.0003090119,0.000003140284,0.00004286867],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002948614,"threshold_uncertainty_score":0.005862892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0138347985585874,"score_gpt":0.2504044069735727,"score_spread":0.2365696084149853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}