{"id":"W4366609292","doi":"10.1212/wnl.0000000000207305","title":"Genetic Moderation of the Association of β-Amyloid With Cognition and MRI Brain Structure in Alzheimer Disease","year":2023,"lang":"en","type":"article","venue":"Neurology","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Parkinsonfonden; National Institutes of Health; IXICO; Genentech; Marcus och Amalia Wallenbergs minnesfond; Skånes universitetssjukhus; Sveriges Läkarförbund; Vetenskapsrådet; Eisai; Lunds Universitet; GHR Foundation; Northern California Institute for Research and Education; Servier; Knut och Alice Wallenbergs Stiftelse; Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse; Foundation for Neurologic Diseases; Pfizer; Biogen; BioClinica; Australian Government; F. Hoffmann-La Roche; Synarc; University of Southern California; Brigham and Women's Hospital; Medpace; Bristol-Myers Squibb; Eli Lilly and Company; Novartis Pharmaceuticals Corporation; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Parkinson Research Foundation; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Cognition; Neuroimaging; Alzheimer's disease; Minor allele frequency; Cognitive decline; Allele; Alzheimer's Disease Neuroimaging Initiative; Disease; Psychology; Imaging genetics; Genetic association; Medicine; Oncology; Internal medicine; Neuroscience; Dementia; Allele frequency; Genetics; Biology; Gene; Genotype; Single-nucleotide polymorphism","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001702715,0.0005220685,0.0002927484,0.0005197657,0.0003836146,0.0005434753,0.0004582908,0.000609913,0.002770877],"category_scores_gemma":[0.003178929,0.0002155339,0.0009422353,0.0004532656,0.0005217387,0.0002548516,0.0004674782,0.0003869167,0.000183085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001649323,"about_ca_system_score_gemma":0.0003093551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006805588,"about_ca_topic_score_gemma":0.005571743,"domain_scores_codex":[0.9992489,0.0003058494,0.00007472046,0.0002168249,0.00007740633,0.00007623198],"domain_scores_gemma":[0.9981191,0.0009467739,0.0004103413,0.0002603678,0.0001105012,0.0001528189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001913374,0.0000775226,0.9849961,0.00003531948,0.001284872,0.0004130239,0.0002634613,0.0003151674,0.006729987,0.0001533758,0.0001984047,0.003619258],"study_design_scores_gemma":[0.00005987829,0.0001787699,0.9972529,0.000008378051,0.0003279922,0.0003911448,0.00008531459,0.0005630259,0.0007196967,0.0002260522,0.0001797013,0.000007076758],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990307,0.0001537982,0.0002638051,0.00006105874,0.000005777334,0.000006417617,0.0001741259,0.000007661217,0.000296606],"genre_scores_gemma":[0.9994473,0.00002557327,0.0002400583,0.00002324368,0.000009034992,0.00000518119,0.000110676,0.000003945941,0.0001349679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006805588,"threshold_uncertainty_score":0.01353198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01054916288951153,"score_gpt":0.2714231847285535,"score_spread":0.260874021839042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}