{"id":"W4366694476","doi":"10.1016/j.xgen.2023.100304","title":"Systematic elucidation of genetic mechanisms underlying cholesterol uptake","year":2023,"lang":"en","type":"article","venue":"Cell Genomics","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"National Human Genome Research Institute; National Heart, Lung, and Blood Institute; Qatar Biomedical Research Institute, Hamad Bin Khalifa University; National Organization for Rare Disorders; National Institutes of Health; National University of Singapore; National Institute of General Medical Sciences; American Heart Association; American Cancer Society","keywords":"Computational biology; Biology; Evolutionary biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004653552,0.0004372759,0.0004422994,0.0007960921,0.0002983379,0.0005095219,0.0003970948,0.0006126501,0.001849922],"category_scores_gemma":[0.0003779937,0.0002072703,0.0004210062,0.0005124112,0.000668509,0.0002814136,0.0008151932,0.0007870638,0.0004986131],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004754342,"about_ca_system_score_gemma":0.000714548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001396593,"about_ca_topic_score_gemma":0.002612986,"domain_scores_codex":[0.9997228,0.00004980129,0.00003447615,0.00009058862,0.0000663124,0.00003609196],"domain_scores_gemma":[0.9995689,0.0001403407,0.0001271577,0.00008414347,0.00003672035,0.00004283744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000123527,0.00002294769,0.001686275,0.0001179109,0.00002877929,0.0002603355,0.00004433047,0.0002793735,0.9872416,0.001835966,0.0001069134,0.008251981],"study_design_scores_gemma":[0.00006449004,0.0005528149,0.05598851,0.0001042194,0.0002745914,0.003473287,0.0001754445,0.005318958,0.8965871,0.002678558,0.03472108,0.00006098899],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8963725,0.006790926,0.08389383,0.0009769336,0.0001267051,0.0002174031,0.005060125,0.0004468965,0.006114673],"genre_scores_gemma":[0.9432535,0.006416885,0.04015216,0.0004445128,0.00003865003,0.000123091,0.003653666,0.0001707474,0.005746762],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001849922,"threshold_uncertainty_score":0.006188571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03256221503113672,"score_gpt":0.2630670830625247,"score_spread":0.230504868031388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}