{"id":"W4366722963","doi":"10.21203/rs.3.rs-2777459/v1","title":"Efficacy of Olanzapine, Netupitant, and Palonosetron in Controlling Nausea and Vomiting Associated with Highly Emetogenic Chemotherapy in Patients with Breast Cancer (OLNEPA)","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Nausea and vomiting management","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Research (Canada)","funders":"","keywords":"Palonosetron; Nausea; Chemotherapy-induced nausea and vomiting; Medicine; Vomiting; Aprepitant; Olanzapine; Anesthesia; Adverse effect; Clinical endpoint; Dexamethasone; Internal medicine; Chemotherapy; Gastroenterology; Antiemetic; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001713987,0.0003213435,0.000896095,0.0009792709,0.0000750996,0.00006829131,0.0001492622,0.0002284699,0.00001374259],"category_scores_gemma":[0.0003789646,0.0002478657,0.0000502574,0.0008463708,0.0001832612,0.00006055922,0.0003050074,0.00121771,9.543097e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004497392,"about_ca_system_score_gemma":0.0002867692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002007399,"about_ca_topic_score_gemma":0.002111723,"domain_scores_codex":[0.9966706,0.0003050072,0.0005045083,0.0007433763,0.001046666,0.0007298463],"domain_scores_gemma":[0.998079,0.0006339161,0.0002468217,0.0003789279,0.0004887111,0.0001726172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005524451,0.0004084845,0.9892024,0.001377832,0.0004123713,0.00006818291,0.0004280276,0.0002199993,0.00007664919,0.00001752844,0.0000471663,0.002216948],"study_design_scores_gemma":[0.0254684,0.000765011,0.9632205,0.008791137,0.00006994538,0.000001034173,0.0002088168,0.001161231,0.00004372248,0.00002936026,0.000009657935,0.0002311472],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953914,0.0006182722,0.000007623199,0.0009652053,0.00002865788,0.002704505,0.0001830974,0.00005177638,0.00004944651],"genre_scores_gemma":[0.9983417,0.0009142393,0.000069661,0.0000320208,0.00007473731,0.0001736251,0.0001943523,0.00009228009,0.0001074251],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02598183,"threshold_uncertainty_score":0.9999974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03732978616958686,"score_gpt":0.3515054142130598,"score_spread":0.3141756280434729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}