{"id":"W4366722963","doi":"10.21203/rs.3.rs-2777459/v1","title":"Efficacy of Olanzapine, Netupitant, and Palonosetron in Controlling Nausea and Vomiting Associated with Highly Emetogenic Chemotherapy in Patients with Breast Cancer (OLNEPA)","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Nausea and vomiting management","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Research (Canada)","funders":"","keywords":"Palonosetron; Nausea; Chemotherapy-induced nausea and vomiting; Medicine; Vomiting; Aprepitant; Olanzapine; Anesthesia; Adverse effect; Clinical endpoint; Dexamethasone; Internal medicine; Chemotherapy; Gastroenterology; Antiemetic; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008638371,0.000388841,0.0009197228,0.0001987409,0.0001544654,0.0003753944,0.0003651793,0.0003203795,0.001303372],"category_scores_gemma":[0.001588383,0.0001767819,0.0005497843,0.0001965999,0.0002288341,0.0002861232,0.0001841803,0.000812554,0.0001676647],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003984388,"about_ca_system_score_gemma":0.0004696818,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004545284,"about_ca_topic_score_gemma":0.00139371,"domain_scores_codex":[0.999658,0.0001738782,0.00006513128,0.00003171473,0.0000439947,0.00002725242],"domain_scores_gemma":[0.9992856,0.0001945398,0.0002636918,0.00004584903,0.00004301198,0.0001672174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5655128,0.02064515,0.02661945,0.002296661,0.001857424,0.0002844443,0.0002791923,0.001306249,0.03441051,0.0001072893,0.001001501,0.3456794],"study_design_scores_gemma":[0.2118599,0.6431929,0.1296277,0.0001847756,0.001292321,0.0009130652,0.0001635491,0.002403115,0.008262977,0.0001336974,0.001916489,0.00004940794],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972038,0.001905262,0.0001150096,0.00008290391,0.00002065999,0.0002342083,0.00009420522,0.00001753875,0.0003264732],"genre_scores_gemma":[0.9978143,0.0008694864,0.0006446416,0.0001296991,0.00003037078,0.0001838982,0.0001447757,0.000003298156,0.0001794783],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001303372,"threshold_uncertainty_score":0.004568458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03732978616958686,"score_gpt":0.3515054142130598,"score_spread":0.3141756280434729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}