{"id":"W4366742133","doi":"10.1021/acs.langmuir.2c03492","title":"Phosphatidylinositol 4,5-Bisphosphate Sensing Lipid Raft via Inter-Leaflet Coupling Regulated by Acyl Chain Length of Sphingomyelin","year":2023,"lang":"en","type":"article","venue":"Langmuir","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions; Natural Science Foundation of Shandong Province; Natural Science Foundation of Jiangsu Province; National Natural Science Foundation of China","keywords":"Biophysics; Lipid raft; Phosphatidylinositol 4,5-bisphosphate; Lipid bilayer; Sphingomyelin; Phosphatidylinositol; Chemistry; Raft; Membrane; Pleckstrin homology domain; Cell membrane; Signal transduction; Cell biology; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000687811,0.0001803883,0.0001222981,0.00005940388,0.0002133427,0.0002519791,0.0002193705,0.0001988871,0.0006408674],"category_scores_gemma":[0.0001241216,0.0001191567,0.0001472931,0.00005822854,0.0003432233,0.0003793291,0.0002055144,0.0002732833,0.0001323326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003145438,"about_ca_system_score_gemma":0.0002925843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001223393,"about_ca_topic_score_gemma":0.0009320137,"domain_scores_codex":[0.9999607,0.000006536656,0.000001194209,0.000008276183,0.00001024619,0.00001308996],"domain_scores_gemma":[0.9999685,0.000005237735,0.00001006927,0.000002203885,0.000003895905,0.00001007251],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001241105,0.00005254824,0.0006991444,0.00005239192,0.00001618193,0.0001048921,0.00004691211,0.01225373,0.9811447,0.003814561,0.0001370214,0.001553824],"study_design_scores_gemma":[0.00009635006,0.000158862,0.003144836,0.00001050266,0.00002514249,0.00008901929,0.00009536486,0.4480981,0.5443478,0.001670966,0.00222241,0.00004061918],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933084,0.00009821553,0.004870854,0.00008109272,0.0000149727,0.00001057493,0.00002629812,0.00004978517,0.001539805],"genre_scores_gemma":[0.9982032,0.0001263549,0.001219421,0.00001655909,0.00000174175,0.000009498699,0.00001957523,0.000006093074,0.0003976127],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001223393,"threshold_uncertainty_score":0.002432525,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007159255423592418,"score_gpt":0.2397874224042888,"score_spread":0.2326281669806964,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}