{"id":"W4366742703","doi":"10.1002/1878-0261.13441","title":"Isocitrate dehydrogenase 1 sustains a hybrid cytoplasmic–mitochondrial tricarboxylic acid cycle that can be targeted for therapeutic purposes in prostate cancer","year":2023,"lang":"en","type":"article","venue":"Molecular Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier de l'Université Laval; Université Laval","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Institute of Cancer Research; Canada Foundation for Innovation","keywords":"Isocitrate dehydrogenase; Citric acid cycle; Tricarboxylic acid; Prostate cancer; Mitochondrion; IDH1; Cytoplasm; Cancer research; Biochemistry; Chemistry; Biology; Enzyme; Cancer; Medicine; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001180701,0.0003447252,0.0002960748,0.0003006109,0.0001891402,0.0004675379,0.0002288099,0.000253488,0.0007495985],"category_scores_gemma":[0.00009058316,0.0001297643,0.000239358,0.0004290786,0.0002210076,0.0002153215,0.0002112689,0.000550682,0.0003251716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004502894,"about_ca_system_score_gemma":0.0003326433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008399764,"about_ca_topic_score_gemma":0.001749631,"domain_scores_codex":[0.9998919,0.00001053546,0.000004898885,0.00002740699,0.00004668118,0.00001855575],"domain_scores_gemma":[0.9999498,0.000003964926,0.00001498455,0.000007162621,0.00001049244,0.00001354742],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001414434,0.0000218623,0.0004737867,0.0000977896,0.00001779956,0.00003958457,0.00001501179,0.000142398,0.9929255,0.0003902451,0.0001471566,0.005587406],"study_design_scores_gemma":[0.00002310904,0.000322338,0.01005322,0.00001731722,0.00006342861,0.0004901381,0.00004452719,0.001636042,0.9707232,0.0003516306,0.0162595,0.00001560719],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9120167,0.03962856,0.03855524,0.0006609021,0.0002200134,0.000103701,0.002416313,0.0009195813,0.005478844],"genre_scores_gemma":[0.9854031,0.006407985,0.004288606,0.0001143884,0.00002179828,0.00004698098,0.001491373,0.00004187171,0.002183906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008399764,"threshold_uncertainty_score":0.00326705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03511277330948553,"score_gpt":0.3543559853976431,"score_spread":0.3192432120881576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}