{"id":"W4366742718","doi":"10.1038/s41467-023-38001-x","title":"RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Terry Fox Research Institute; University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Memorial Sloan-Kettering Cancer Center; Leukemia and Lymphoma Society; Alex's Lemonade Stand Foundation for Childhood Cancer; American Society of Hematology; Damon Runyon Cancer Research Foundation; National Cancer Institute; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Cell biology; Unfolded protein response; Progenitor cell; Biology; Proteostasis; Haematopoiesis; Stem cell; Endoplasmic reticulum; RNA-binding protein; Homeostasis; RNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001576431,0.0003437116,0.0001965856,0.0003517733,0.0001786627,0.0003604,0.0001949172,0.0002257889,0.000647079],"category_scores_gemma":[0.00009897391,0.0001672719,0.0001664055,0.0001223813,0.0002759905,0.000174725,0.000278224,0.0003665368,0.000391268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000233639,"about_ca_system_score_gemma":0.0002185473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002109018,"about_ca_topic_score_gemma":0.0005323757,"domain_scores_codex":[0.9998429,0.00002090337,0.000008442623,0.00004868032,0.00004646216,0.00003253638],"domain_scores_gemma":[0.9998356,0.00001519868,0.00006533399,0.000024943,0.00001725423,0.00004161071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000200433,0.000002867282,0.00007085741,0.000005876434,9.715595e-7,0.00001807173,0.000002436779,0.000019598,0.9993365,0.00005145492,0.00001214876,0.000459228],"study_design_scores_gemma":[0.000005243671,0.00007815965,0.004433462,0.000003456731,0.000006943437,0.0002096783,0.00001452069,0.0009431491,0.9924494,0.0000593751,0.001793524,0.000003033374],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887528,0.002002007,0.00680479,0.000101575,0.00002300628,0.00001748072,0.0003861363,0.0002675652,0.001644569],"genre_scores_gemma":[0.9947063,0.00061513,0.002262561,0.00004071573,0.00001216128,0.00001559647,0.0004660118,0.0000480079,0.001833481],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000647079,"threshold_uncertainty_score":0.002164662,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01538939732712154,"score_gpt":0.2596182409989721,"score_spread":0.2442288436718506,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}