{"id":"W4366742757","doi":"10.1016/j.celrep.2023.112372","title":"NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency","year":2023,"lang":"en","type":"article","venue":"Cell Reports","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"National Institute of Mental Health; Uehara Memorial Foundation; Wellcome Trust; Cancer Research UK; Biotechnology and Biological Sciences Research Council; National Institute for Health and Care Research; National Institute on Aging; Surgical Reconstruction and Microbiology Research Centre; LEO Fondet; University of Balamand; Fundação de Amparo à Pesquisa do Estado de São Paulo; National Institutes of Health; University of Birmingham; Japan Society for the Promotion of Science London; Japan Society for the Promotion of Science; Medical Research Council; International Seafood Sustainability Foundation; Emerald Foundation; Department of Science and Technology, Ministry of Science and Technology, India; LifeArc; Eunice Kennedy Shriver National Institute of Child Health and Human Development; UK-India Education and Research Initiative; National Institute of Neurological Disorders and Stroke; International Pediatric Research Foundation","keywords":"Cytotoxicity; Autophagy; NAD+ kinase; Cell biology; Chemistry; Biology; Biochemistry; Apoptosis; Enzyme; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002210645,0.0003178038,0.0004591155,0.0002564109,0.0002025705,0.0003371139,0.0002408184,0.0003077328,0.001046699],"category_scores_gemma":[0.0001443362,0.0001187582,0.0003230393,0.0002343726,0.0002415018,0.0001530049,0.0003746868,0.0004827911,0.0004204832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002801292,"about_ca_system_score_gemma":0.00033339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001272759,"about_ca_topic_score_gemma":0.001404037,"domain_scores_codex":[0.9998235,0.00002818808,0.00003383292,0.00003506939,0.00004823514,0.00003118363],"domain_scores_gemma":[0.9999254,0.00001655608,0.0000138173,0.00001751216,0.00001366867,0.00001303396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004737219,0.0001035088,0.001247729,0.00008707016,0.00003158724,0.0008631581,0.00008506615,0.0001292112,0.9939545,0.0002459774,0.0001337777,0.002644728],"study_design_scores_gemma":[0.00003512391,0.0007433247,0.00946363,0.00001992173,0.00006355353,0.002552043,0.0001436008,0.001023567,0.9826801,0.0002322307,0.003032303,0.00001058484],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936355,0.001741852,0.001633283,0.0000774013,0.00004234968,0.00003993662,0.0004999927,0.00006179886,0.002267696],"genre_scores_gemma":[0.9963623,0.0009575576,0.0007938469,0.0000468512,0.000004689542,0.00004290943,0.0006667798,0.000009158994,0.00111601],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001272759,"threshold_uncertainty_score":0.003501534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01449083510277236,"score_gpt":0.2686208294769928,"score_spread":0.2541299943742205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}