{"id":"W4366742757","doi":"10.1016/j.celrep.2023.112372","title":"NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency","year":2023,"lang":"en","type":"article","venue":"Cell Reports","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"National Institute of Mental Health; Uehara Memorial Foundation; Wellcome Trust; Cancer Research UK; Biotechnology and Biological Sciences Research Council; National Institute for Health and Care Research; National Institute on Aging; Surgical Reconstruction and Microbiology Research Centre; LEO Fondet; University of Balamand; Fundação de Amparo à Pesquisa do Estado de São Paulo; National Institutes of Health; University of Birmingham; Japan Society for the Promotion of Science London; Japan Society for the Promotion of Science; Medical Research Council; International Seafood Sustainability Foundation; Emerald Foundation; Department of Science and Technology, Ministry of Science and Technology, India; LifeArc; Eunice Kennedy Shriver National Institute of Child Health and Human Development; UK-India Education and Research Initiative; National Institute of Neurological Disorders and Stroke; International Pediatric Research Foundation","keywords":"Cytotoxicity; Autophagy; NAD+ kinase; Cell biology; Chemistry; Biology; Biochemistry; Apoptosis; Enzyme; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002204071,0.0001386365,0.0002183704,0.000187374,0.00008761103,0.00001231025,0.00004739396,0.00007227154,0.0001687476],"category_scores_gemma":[0.00004693736,0.0001119781,0.00005902228,0.0004914608,0.0000658805,0.00005706774,0.0000254092,0.0001567289,0.00004443381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004832241,"about_ca_system_score_gemma":0.0001376344,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007087122,"about_ca_topic_score_gemma":0.00002792533,"domain_scores_codex":[0.9987026,0.00002838245,0.0003144946,0.0003470773,0.0003068461,0.0003005919],"domain_scores_gemma":[0.9992695,0.00003271235,0.0001263727,0.0003915239,0.00003857029,0.0001413076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001605376,0.001186023,0.5184427,0.0003243788,0.00003682183,0.06117264,0.001164515,0.0003598958,0.412843,0.0002569167,0.002962706,0.001089876],"study_design_scores_gemma":[0.0008395762,0.0003325839,0.8225994,0.00006493692,0.00004501892,0.0003745148,0.00008950078,0.0001669704,0.1737318,0.0007426667,0.000830462,0.00018262],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907949,0.0002258226,0.0000221665,0.00009830525,0.0001244754,0.0003433218,0.000001450897,0.0002577433,0.008131843],"genre_scores_gemma":[0.9981698,0.00005449348,0.00003261234,0.0002142506,0.00007023004,0.00004600907,0.00006926239,0.00003005414,0.001313224],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3041567,"threshold_uncertainty_score":0.4566333,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01449083510277236,"score_gpt":0.2686208294769928,"score_spread":0.2541299943742205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}