{"id":"W4366742785","doi":"10.1111/cpr.13475","title":"Genome‐wide screen for anticancer drug resistance in haploid human embryonic stem cells","year":2023,"lang":"en","type":"article","venue":"Cell Proliferation","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Azrieli Foundation; Israel Science Foundation","keywords":"Biology; Gene; Drug resistance; Embryonic stem cell; Genetics; Genome; Drug discovery; Cancer cell; Genetic screen; Cancer; Cancer research; Phenotype; Bioinformatics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002110173,0.0001072627,0.0001000189,0.00006284947,0.0000745697,0.00002583526,0.0001003877,0.00007198897,0.000004386794],"category_scores_gemma":[0.000007564306,0.0001181113,0.00004524795,0.0001222304,0.00001513155,0.000003975143,0.00003372725,0.00005275709,0.00001405969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001948191,"about_ca_system_score_gemma":0.00003485283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003150738,"about_ca_topic_score_gemma":0.0002507434,"domain_scores_codex":[0.9992254,0.00001999015,0.0001703293,0.0002788762,0.00007911045,0.0002262467],"domain_scores_gemma":[0.9996639,0.0000110302,0.00003600127,0.0002072021,0.00004266634,0.00003923545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003050308,0.00001560977,0.001329903,0.00009014312,0.000006240054,9.701325e-7,0.0001223304,0.002820386,0.9928506,0.00002499856,0.002619466,0.00008886385],"study_design_scores_gemma":[0.0005841873,0.00004674114,0.005554199,0.00001409095,0.000007719391,1.935036e-7,0.00005169024,0.00100761,0.97344,0.00007633639,0.01903665,0.0001805634],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884062,0.0007803753,0.00945065,0.0001797698,0.0001082403,0.0005257644,0.00001488643,0.00003238123,0.0005017553],"genre_scores_gemma":[0.9876694,0.0001306606,0.0003874159,0.00006845131,0.000187956,0.0001076397,0.0001966376,0.00002813746,0.0112237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01941057,"threshold_uncertainty_score":0.4816437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01032227806540742,"score_gpt":0.2746237826109162,"score_spread":0.2643015045455088,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}