{"id":"W4366742785","doi":"10.1111/cpr.13475","title":"Genome‐wide screen for anticancer drug resistance in haploid human embryonic stem cells","year":2023,"lang":"en","type":"article","venue":"Cell Proliferation","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Azrieli Foundation; Israel Science Foundation","keywords":"Biology; Gene; Drug resistance; Embryonic stem cell; Genetics; Genome; Drug discovery; Cancer cell; Genetic screen; Cancer; Cancer research; Phenotype; Bioinformatics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003108887,0.0003845433,0.0005465918,0.0004934662,0.0001525682,0.0003496657,0.0003257795,0.0004282836,0.001567392],"category_scores_gemma":[0.0002701833,0.0002179804,0.0003954596,0.0004267461,0.0001749571,0.00009445397,0.0002557105,0.0005323354,0.0004119009],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002761345,"about_ca_system_score_gemma":0.0002675711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005623919,"about_ca_topic_score_gemma":0.001210186,"domain_scores_codex":[0.9997407,0.00004173321,0.00003158669,0.00006095075,0.00009871589,0.00002643716],"domain_scores_gemma":[0.9998248,0.00007374059,0.00004248181,0.00002418335,0.00001780884,0.0000171041],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002522715,0.00001678594,0.000221088,0.00003170208,0.00001130874,0.00003976047,0.00000814249,0.0002257055,0.9980505,0.00004544895,0.00004729064,0.001277096],"study_design_scores_gemma":[0.00001925266,0.0003654699,0.007176455,0.000008172132,0.00006448602,0.0003294417,0.00003146054,0.002565887,0.9850835,0.00005761172,0.004288375,0.000009847277],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9656783,0.001667296,0.02250969,0.0002262348,0.00004527307,0.0003181501,0.006630733,0.0005556715,0.002368678],"genre_scores_gemma":[0.9511195,0.002259124,0.02879238,0.0003338985,0.00001034021,0.000362502,0.01104556,0.0002109503,0.005865871],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001567392,"threshold_uncertainty_score":0.00524348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01032227806540742,"score_gpt":0.2746237826109162,"score_spread":0.2643015045455088,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}