{"id":"W4366750874","doi":"10.1016/j.jid.2023.04.007","title":"Upregulated MicroRNA-21 Drives the Proliferation of Lymphatic Malformation Endothelial Cells by Inhibiting PDCD4","year":2023,"lang":"en","type":"article","venue":"Journal of Investigative Dermatology","topic":"Vascular Malformations and Hemangiomas","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Arkansas Biosciences Institute; National Heart, Lung, and Blood Institute; American Society of Preventive Oncology; American Society of Pediatric Otolaryngology; Arkansas Children’s Hospital Research Institute","keywords":"Lymphatic system; Lymphatic Endothelium; Somatic cell; Downregulation and upregulation; Biology; microRNA; Stroma; Cell biology; Lesion; Cancer research; Pathology; Medicine; Immunology; Genetics; Immunohistochemistry; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003813845,0.0001316988,0.0004022793,0.0003094975,0.0001318836,0.00001857318,0.0001106956,0.0001037539,0.00001981437],"category_scores_gemma":[0.0003208007,0.00008740385,0.0001734201,0.0004563666,0.0003390068,0.0003180578,0.00003357698,0.0001731638,0.00003266064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004570894,"about_ca_system_score_gemma":0.0001981469,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003666641,"about_ca_topic_score_gemma":0.000001549903,"domain_scores_codex":[0.9983271,0.0001947716,0.0009091959,0.00008030951,0.0002945658,0.0001940465],"domain_scores_gemma":[0.9982828,0.000136122,0.0009049025,0.0001218147,0.0004621046,0.00009222481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004868919,0.00004873327,0.001399054,0.0001925025,0.0001984625,0.00003365391,0.005114713,0.0002041353,0.9812069,0.0005803764,0.01070085,0.0002719164],"study_design_scores_gemma":[0.001241397,0.0001115869,0.003109935,0.0002528747,0.0001352003,0.001918992,0.001584087,0.004137145,0.9858448,0.0009797413,0.0006078983,0.00007635827],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916889,0.000183238,0.000453305,0.007036292,0.0001313199,0.0002988372,0.0000127742,0.00002143054,0.0001739167],"genre_scores_gemma":[0.9981797,0.0000719575,0.001098883,0.0004426008,0.00006802372,0.000007940861,0.00003826916,0.00001423313,0.0000783646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01009295,"threshold_uncertainty_score":0.3564225,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01561706208569621,"score_gpt":0.2495483321238263,"score_spread":0.2339312700381301,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}