{"id":"W4366769160","doi":"10.1038/s41420-023-01420-2","title":"PARP1 mediated PARylation contributes to myogenic progression and glucocorticoid transcriptional response","year":2023,"lang":"en","type":"article","venue":"Cell Death Discovery","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Trent University; Nottingham Trent University","keywords":"Myogenesis; Biology; PARP1; Cell biology; Skeletal muscle; Myocyte; Regulator; Glucocorticoid; Endocrinology; Gene; Genetics; Poly ADP ribose polymerase","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001868146,0.0002952911,0.0002278664,0.0001728507,0.0002389665,0.0005518924,0.0002682644,0.0004148137,0.003795461],"category_scores_gemma":[0.0001573947,0.0002443257,0.0003935814,0.0001377019,0.0002157864,0.0002945752,0.0003454124,0.0007549699,0.001274916],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002527042,"about_ca_system_score_gemma":0.0001530776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002832748,"about_ca_topic_score_gemma":0.0003492719,"domain_scores_codex":[0.999782,0.00002995089,0.00001579696,0.00008341151,0.00004088336,0.00004794257],"domain_scores_gemma":[0.9997718,0.00002504203,0.00009006637,0.00003169724,0.00002972468,0.00005167614],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002004123,0.00002695417,0.0009296006,0.00007661741,0.000009187781,0.00009727864,0.00003389688,0.00009421846,0.9938253,0.0003016518,0.0002121886,0.004192528],"study_design_scores_gemma":[0.00003368381,0.0006076431,0.1106265,0.00003289254,0.00005579805,0.001821695,0.0001378661,0.001844638,0.8657309,0.0005208417,0.01856216,0.00002539391],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9515491,0.01593468,0.02107665,0.000874497,0.0002349045,0.00007027505,0.002560185,0.0004739625,0.00722578],"genre_scores_gemma":[0.9844508,0.003642358,0.002870127,0.0001726035,0.00006875071,0.00003359771,0.001746251,0.00005137648,0.006964005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003795461,"threshold_uncertainty_score":0.0126971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02514070448689568,"score_gpt":0.3160210587877392,"score_spread":0.2908803543008436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}