{"id":"W4366771712","doi":"10.3390/microorganisms11041078","title":"In Silico Analysis of Changes in Predicted Metabolic Capabilities of Intestinal Microbiota after Fecal Microbial Transplantation for Treatment of Recurrent Clostridioides difficile Infection","year":2023,"lang":"en","type":"article","venue":"Microorganisms","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Hospital Edmonton; University of Calgary; University of Alberta","funders":"Alberta Health Services","keywords":"Clostridioides; Fecal bacteriotherapy; Feces; In silico; Microbiology; Biology; Transplantation; Clostridium difficile; Medicine; Internal medicine; Antibiotics; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002510952,0.0002291174,0.0009821516,0.001793243,0.00001978268,0.000006406302,0.00007794933,0.000153243,0.000115952],"category_scores_gemma":[0.0001137253,0.0002090524,0.0002921177,0.002561139,0.0001727869,0.0000407479,0.0000258221,0.0000918807,0.000002050547],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002234553,"about_ca_system_score_gemma":0.0001737851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00199153,"about_ca_topic_score_gemma":0.004880477,"domain_scores_codex":[0.9982258,0.00009294032,0.0007703877,0.0003545315,0.0002068018,0.0003495553],"domain_scores_gemma":[0.9990301,0.0002552287,0.0001767398,0.0002527716,0.0002243863,0.0000607709],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00211497,0.001161295,0.0608878,0.0007667047,0.0003519417,0.00001377963,0.003075934,0.00007710017,0.9298688,0.000008455254,0.00003208427,0.001641131],"study_design_scores_gemma":[0.00247694,0.001286931,0.2217461,0.0001783012,0.0008508638,0.000009363283,0.0002680924,0.0002309185,0.7727453,0.000005261447,0.00009665948,0.000105295],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996801,0.0004855795,0.00002624026,0.0002039307,0.00009298434,0.001003084,0.001355215,0.00002353938,0.000008468951],"genre_scores_gemma":[0.9973352,0.0015065,0.0001432681,0.000006900204,0.00005368999,0.0001238379,0.0007227669,0.00002638736,0.000081454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1608583,"threshold_uncertainty_score":0.8524911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02123728270175096,"score_gpt":0.2974907160890515,"score_spread":0.2762534333873006,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}