{"id":"W4366772115","doi":"10.3390/ddc2020015","title":"Design, Synthesis and In Vitro Studies of 3-Amidocoumarins as Novel Antibiofilm Agents","year":2023,"lang":"en","type":"article","venue":"Drugs and Drug Candidates","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Banaras Hindu University; Council for Scientific and Industrial Research, South Africa; Science and Engineering Research Board; Canadian Institute of Steel Construction","keywords":"Biofilm; Pseudomonas aeruginosa; Quorum sensing; Docking (animal); Chemistry; Microbiology; Antibiotics; In vitro; Context (archaeology); Antibiotic resistance; Bacteria; Biology; Biochemistry; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002564141,0.0001395128,0.0002341256,0.00008574294,0.00006576267,0.00002286848,0.00005361166,0.00006860497,0.000002902944],"category_scores_gemma":[0.00009536296,0.0001200094,0.00002866335,0.0001223024,0.0001335014,0.000006307854,0.0001585524,0.00003923617,0.000002635381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005446745,"about_ca_system_score_gemma":0.00002578913,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001971145,"about_ca_topic_score_gemma":0.00003713744,"domain_scores_codex":[0.9992215,0.00003736074,0.0001856562,0.0002774835,0.00006818227,0.00020981],"domain_scores_gemma":[0.9996493,0.00006913539,0.00006443207,0.0001310848,0.00003420389,0.0000517941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000178569,0.00002180856,0.001914626,0.00005277712,0.00005554194,0.000003980524,0.0004144456,0.000004853171,0.9943753,0.00001117675,0.000408719,0.002558176],"study_design_scores_gemma":[0.0004142393,0.00004006781,0.004233219,0.00005096109,0.00002055385,0.000006357974,0.001010317,0.0001248079,0.9928121,0.00002567723,0.001107948,0.0001537537],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985232,0.000862465,0.000003397146,0.0002014157,0.00008127098,0.0001275421,0.00004526863,0.00001075827,0.0001446702],"genre_scores_gemma":[0.9965912,0.002684446,0.0003122227,0.00008117856,0.00004214656,0.000005857121,0.00004406911,0.00001436424,0.0002245945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002404423,"threshold_uncertainty_score":0.489384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01985490917465887,"score_gpt":0.2724799531335821,"score_spread":0.2526250439589232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}