{"id":"W4366772325","doi":"10.1186/s11658-023-00438-9","title":"Deciphering STAT3 signaling potential in hepatocellular carcinoma: tumorigenesis, treatment resistance, and pharmacological significance","year":2023,"lang":"en","type":"review","venue":"Cellular & Molecular Biology Letters","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Universiti Kebangsaan Malaysia; Ministry of Higher Education, Malaysia","keywords":"Cancer research; STAT3; Radioresistance; Carcinogenesis; STAT protein; Metastasis; Tumor progression; Cancer; Signal transduction; Biology; Epithelial–mesenchymal transition; Hepatocellular carcinoma; Medicine; Radiation therapy; Internal medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002237986,0.0003425817,0.0005036038,0.0007556519,0.0001552282,0.0005437137,0.0002446838,0.0003821784,0.001214816],"category_scores_gemma":[0.0001630747,0.0001059548,0.0004391983,0.0006964998,0.0001775761,0.00059109,0.0002312505,0.0007581114,0.0003161284],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004410851,"about_ca_system_score_gemma":0.0005723133,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005307703,"about_ca_topic_score_gemma":0.001283769,"domain_scores_codex":[0.9999166,0.00001388857,0.00001265859,0.00001156016,0.00002798685,0.00001732886],"domain_scores_gemma":[0.9999458,0.00001596719,0.00001201061,0.000001701735,0.00001685975,0.000007769236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006821185,0.0001672576,0.005326272,0.02597273,0.0002820668,0.001390722,0.0003924892,0.001876256,0.2349854,0.007792018,0.01543873,0.7056939],"study_design_scores_gemma":[0.0001468511,0.001621576,0.03075174,0.002466584,0.001177563,0.009208113,0.0006670383,0.003666046,0.1231936,0.006698758,0.820242,0.0001600714],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01404104,0.9808083,0.001164804,0.0008653054,0.0002361142,0.00002021485,0.0001720097,0.00003197299,0.002660295],"genre_scores_gemma":[0.06037587,0.9350899,0.0009921608,0.0006055456,0.0004508405,0.00003257022,0.0005454387,0.000008422519,0.00189928],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001214816,"threshold_uncertainty_score":0.004063904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02591124622813935,"score_gpt":0.2994801443200379,"score_spread":0.2735688980918985,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}