{"id":"W4366775475","doi":"10.3390/cells12081199","title":"Parsimonious Effect of Pentoxifylline on Angiogenesis: A Novel Pentoxifylline-Biased Adenosine G Protein-Coupled Receptor Signaling Platform","year":2023,"lang":"en","type":"review","venue":"Cells","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Pentoxifylline; Angiogenesis; Adenosine receptor; Pharmacology; Receptor; Adenosine; G protein-coupled receptor; In vivo; Biology; Medicine; Cancer research; Internal medicine; Agonist; Biotechnology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006980452,0.0009436819,0.00206557,0.0002535835,0.0001070239,0.00004085628,0.0006990602,0.0009019852,0.0001316087],"category_scores_gemma":[0.0001034787,0.0007457181,0.001734071,0.0005082047,0.0001063184,0.000004931866,0.0002156971,0.0002446688,0.0002329975],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009590769,"about_ca_system_score_gemma":0.0003121089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003193532,"about_ca_topic_score_gemma":0.000007456445,"domain_scores_codex":[0.9965613,0.0001300134,0.001123564,0.001078,0.0004565777,0.0006505254],"domain_scores_gemma":[0.9976524,0.0001573332,0.0009003283,0.0009391498,0.0001416689,0.000209097],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006611415,0.0004693002,0.000006754716,0.02945095,0.002083546,0.00002818032,0.00002502838,0.0002117813,0.859619,0.00001359711,0.005866534,0.1015641],"study_design_scores_gemma":[0.0009992532,0.001399805,5.654892e-7,0.007961228,0.0009505114,0.000006282294,0.00000699114,0.00002820816,0.441673,0.000001149041,0.5462001,0.0007729816],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01349691,0.982321,0.0002075276,0.00000921164,0.0005534774,0.002656088,0.000636986,0.00005888486,0.00005987807],"genre_scores_gemma":[0.001553467,0.9911864,0.0003089012,0.00003963993,0.001320047,0.00067509,0.002030405,0.0003250651,0.002560964],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.5403336,"threshold_uncertainty_score":0.9994994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05149763676794378,"score_gpt":0.321038520160898,"score_spread":0.2695408833929542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}