{"id":"W4366779011","doi":"10.1016/j.bbrc.2023.04.026","title":"Structural basis of CDK3 activation by cyclin E1 and inhibition by dinaciclib","year":2023,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; National Key Research and Development Program of China; National Research Council; Canadian Institutes of Health Research; National Research Council Canada; National Natural Science Foundation of China; Canada Foundation for Innovation; University of Saskatchewan","keywords":"Cyclin-dependent kinase; Cyclin A; Cyclin-dependent kinase complex; Cell cycle; Cyclin D; Cell biology; Cyclin B; Biology; Chemistry; Cyclin; Biochemistry; Cell","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007420775,0.000185625,0.0001758101,0.0001039186,0.0003667276,0.000235256,0.0004368236,0.0001743195,0.003333464],"category_scores_gemma":[0.0001308589,0.0001381227,0.0001603836,0.0001037127,0.0002876746,0.0001475357,0.0001797525,0.0005172382,0.0003566936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006347217,"about_ca_system_score_gemma":0.0004805892,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00189516,"about_ca_topic_score_gemma":0.002105983,"domain_scores_codex":[0.9999576,0.000005463542,0.000002493219,0.00000735139,0.000009377765,0.00001765237],"domain_scores_gemma":[0.9999677,0.000008612908,0.000006502325,0.000002979597,0.000002702862,0.0000114231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001559669,0.0001034034,0.0006788506,0.0001358974,0.00002115788,0.000742402,0.00007214424,0.004681144,0.9740427,0.01119244,0.0005436577,0.006226499],"study_design_scores_gemma":[0.000125737,0.0002569167,0.002502966,0.00001077091,0.00002236857,0.0005672548,0.00006586644,0.006785944,0.9814596,0.001073754,0.007108774,0.00002005019],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877418,0.0009902491,0.001880963,0.000396083,0.00006125732,0.00002349415,0.0002357552,0.00007483641,0.008595527],"genre_scores_gemma":[0.9980557,0.000325886,0.0005261618,0.00005048068,0.000003698658,0.000006041225,0.0001471876,0.000005798464,0.0008791218],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003333464,"threshold_uncertainty_score":0.01115161,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07187771495586052,"score_gpt":0.3819511439052671,"score_spread":0.3100734289494065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}