{"id":"W4366782945","doi":"10.1101/2023.04.21.537812","title":"Structure of a dimeric ABC transporter","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"ATP-binding cassette transporter; Linker; Dimer; Transmembrane protein; Chemistry; ATP hydrolysis; Transmembrane domain; Subfamily; Membrane protein; Biochemistry; Protein structure; Transport protein; ATPase; Amino acid; Membrane; Transporter; Enzyme; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008208557,0.0003507824,0.0003553209,0.0002638554,0.0007497933,0.0006518249,0.0005330055,0.0007174309,0.002336438],"category_scores_gemma":[0.0001622821,0.000327692,0.0001953464,0.0002294649,0.0002682958,0.0003963184,0.0001839464,0.0007007168,0.001156765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001087672,"about_ca_system_score_gemma":0.0003812532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001010579,"about_ca_topic_score_gemma":0.0005785674,"domain_scores_codex":[0.9999166,0.00001144351,0.000004879228,0.00003376386,0.00002121438,0.00001210434],"domain_scores_gemma":[0.9999248,0.000007199505,0.0000179124,0.000005450592,0.00002172029,0.00002294597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003432809,0.0002022798,0.002046283,0.0003018804,0.00005487216,0.001132764,0.0001464284,0.006080689,0.9709675,0.006743701,0.0041878,0.007792494],"study_design_scores_gemma":[0.0004493906,0.00118742,0.01943057,0.0001809781,0.0002001231,0.005205429,0.000586556,0.2879448,0.585106,0.009641076,0.08986131,0.0002062727],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9680521,0.00539488,0.01719137,0.001488356,0.0002267105,0.00008779062,0.0005353302,0.0004891392,0.006534189],"genre_scores_gemma":[0.9838066,0.001193263,0.007165315,0.0002070029,0.00004318129,0.00004618463,0.001485313,0.00002877399,0.006024364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002336438,"threshold_uncertainty_score":0.007891595,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01425613672837887,"score_gpt":0.2230958367981342,"score_spread":0.2088397000697554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}