{"id":"W4366813525","doi":"10.7554/elife.84395","title":"The evolution of colistin resistance increases bacterial resistance to host antimicrobial peptides and virulence","year":2023,"lang":"en","type":"article","venue":"eLife","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Infection and Immunity; National Research, Development and Innovation Office; European Research Council; Horizon 2020 Framework Programme; Magyar Tudományos Akadémia; Innovációs és Technológiai Minisztérium; Nemzeti Kutatási Fejlesztési és Innovációs Hivatal; Biotechnology and Biological Sciences Research Council; Cardiff University; Medical Research Council; Directorate for Biological Sciences; Wellcome; National Natural Science Foundation of China; Wellcome Trust","keywords":"Antimicrobial peptides; Colistin; Innate immune system; Virulence; Antibiotic resistance; Biology; Galleria mellonella; Microbiology; Antibiotics; Antimicrobial; Immune system; Immunology; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000367298,0.0001379266,0.0001565503,0.0000375742,0.0002145221,0.00005074753,0.0002579403,0.00008612197,0.000003263144],"category_scores_gemma":[0.0007790207,0.000117523,0.00004336783,0.000225826,0.0002759483,0.000006667624,0.000175413,0.00004923997,0.00001752029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003110109,"about_ca_system_score_gemma":0.0001152851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000608653,"about_ca_topic_score_gemma":0.00130512,"domain_scores_codex":[0.9988514,0.00008822889,0.0002829314,0.0003361236,0.0001719801,0.0002693184],"domain_scores_gemma":[0.9991766,0.00007098583,0.0001319034,0.0004022748,0.0001421625,0.00007607834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007678781,0.0000148394,0.009348484,0.00005185696,0.00001670456,0.000002590678,0.00002911744,0.000002072395,0.9490666,0.0003959796,0.04027233,0.00003157062],"study_design_scores_gemma":[0.0004635127,0.00009436899,0.476476,0.0002175677,0.00001763623,0.00000330453,0.000224335,0.000003765286,0.4046091,0.00005865732,0.1175427,0.000288996],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980074,0.0004478309,0.0001437511,0.0003225675,0.0002202627,0.0002112568,0.0001470131,0.00002346965,0.0004764307],"genre_scores_gemma":[0.9945698,0.0006343776,0.0008530791,0.00007432827,0.0002882225,0.00000905828,0.00003695126,0.00001996548,0.003514159],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5444575,"threshold_uncertainty_score":0.4792447,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006966546203224953,"score_gpt":0.2400830751834831,"score_spread":0.2331165289802582,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}