{"id":"W4366813525","doi":"10.7554/elife.84395","title":"The evolution of colistin resistance increases bacterial resistance to host antimicrobial peptides and virulence","year":2023,"lang":"en","type":"article","venue":"eLife","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Infection and Immunity; National Research, Development and Innovation Office; European Research Council; Horizon 2020 Framework Programme; Magyar Tudományos Akadémia; Innovációs és Technológiai Minisztérium; Nemzeti Kutatási Fejlesztési és Innovációs Hivatal; Biotechnology and Biological Sciences Research Council; Cardiff University; Medical Research Council; Directorate for Biological Sciences; Wellcome; National Natural Science Foundation of China; Wellcome Trust","keywords":"Antimicrobial peptides; Colistin; Innate immune system; Virulence; Antibiotic resistance; Biology; Galleria mellonella; Microbiology; Antibiotics; Antimicrobial; Immune system; Immunology; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002243055,0.0002889269,0.000207985,0.0002008743,0.0001202913,0.0005350531,0.0001455725,0.000535343,0.0009122069],"category_scores_gemma":[0.0002832059,0.0001249506,0.0001844292,0.0001753771,0.0003995434,0.0002889159,0.0006030552,0.0007020831,0.000233923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003183793,"about_ca_system_score_gemma":0.0001553201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000405948,"about_ca_topic_score_gemma":0.000589824,"domain_scores_codex":[0.9998024,0.00003791225,0.00001418906,0.00005237977,0.00004324974,0.00004983372],"domain_scores_gemma":[0.9998317,0.00002459848,0.00007388589,0.00002661998,0.00001339267,0.00002977293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009724863,0.0000198906,0.003054737,0.00003491548,0.000009130642,0.0001554297,0.00003609931,0.0001779864,0.9921675,0.0004340282,0.00005654223,0.003756481],"study_design_scores_gemma":[0.00003493532,0.0007836552,0.08239387,0.00005767429,0.00005541396,0.002368915,0.0005025467,0.004039307,0.8952437,0.001106663,0.0133836,0.00002989239],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994583,0.001098188,0.001921633,0.0003572188,0.00001694554,0.000006274947,0.00008250989,0.00005266435,0.001881578],"genre_scores_gemma":[0.9970639,0.0004657863,0.001364079,0.0001006631,0.000005854282,0.00000518179,0.00004720452,0.00001269809,0.0009345824],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009122069,"threshold_uncertainty_score":0.003051698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006966546203224953,"score_gpt":0.2400830751834831,"score_spread":0.2331165289802582,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}