{"id":"W4366826960","doi":"10.1101/2023.04.22.537920","title":"ESCRT disruption provides evidence against signaling functions for synaptic exosomes","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Research Canada; University of Toronto","funders":"National Institutes of Health","keywords":"ESCRT; Endosome; Microvesicles; Cell biology; Intracellular; Synaptic vesicle; Extracellular vesicles; Biology; Chemistry; Vesicle; Biochemistry; Membrane; microRNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001298681,0.0006295861,0.0004710118,0.0005900206,0.0002077121,0.000561756,0.0003499398,0.0007579398,0.002298896],"category_scores_gemma":[0.0001662607,0.0001972191,0.0005451069,0.0002525787,0.0004696556,0.0003653397,0.0004936474,0.0007527489,0.00100949],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003159389,"about_ca_system_score_gemma":0.0001608819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003923162,"about_ca_topic_score_gemma":0.0004367084,"domain_scores_codex":[0.9997267,0.00001789326,0.00004209646,0.00008168031,0.00009585638,0.00003576921],"domain_scores_gemma":[0.9997256,0.00004234412,0.00008477668,0.0000609292,0.0000270618,0.00005924137],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003632004,0.000009806631,0.0004029236,0.00003711941,0.00002094391,0.0002946878,0.000009007475,0.00004514868,0.998123,0.0002263505,0.00004889326,0.0007458472],"study_design_scores_gemma":[0.000005455825,0.00003818652,0.008676917,0.000008053117,0.00003576974,0.001884705,0.00002215629,0.0005521284,0.9860723,0.0001257233,0.002573662,0.000005030518],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9751363,0.003208321,0.01220239,0.0002613151,0.0001641026,0.00003600473,0.002348606,0.0006915539,0.005951436],"genre_scores_gemma":[0.9877068,0.001209872,0.003432255,0.000130145,0.00001643342,0.00002227013,0.001883952,0.0002185917,0.005379577],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002298896,"threshold_uncertainty_score":0.007690549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03110309634897702,"score_gpt":0.260348749539567,"score_spread":0.22924565319059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}