{"id":"W4366831730","doi":"10.1093/rheumatology/kead104.191","title":"P150 The Triptryium wilfordii derivative celastrol has anti-fibrotic effects in systemic sclerosis","year":2023,"lang":"en","type":"article","venue":"Lara D. Veeken","topic":"Systemic Sclerosis and Related Diseases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Celastrol; Medicine; Fibrosis; Myofibroblast; Pathology; Western blot; CTGF; Cancer research; Immunology; Internal medicine; Biology; Growth factor; Apoptosis; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007357576,0.0002332922,0.0002183638,0.0002397335,0.0001119145,0.0001701626,0.0001478073,0.0002234057,0.001803195],"category_scores_gemma":[0.00006567674,0.00006490947,0.0001765316,0.000136501,0.0001873937,0.000124746,0.0001071229,0.0002905373,0.0004860165],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001270072,"about_ca_system_score_gemma":0.0001448841,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003834162,"about_ca_topic_score_gemma":0.0005299806,"domain_scores_codex":[0.9999453,0.000006900081,0.000005639486,0.00001254302,0.00001563772,0.00001410204],"domain_scores_gemma":[0.9999413,0.0000113631,0.00001373765,0.000006199648,0.000009193304,0.00001824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000190319,0.00002443028,0.00007501381,0.00006418468,0.00000455288,0.00004906814,0.00000796022,0.0000409683,0.9974976,0.000030363,0.00007662745,0.001938843],"study_design_scores_gemma":[0.0000367325,0.0007938217,0.002031585,0.000007146964,0.00002287172,0.0002822403,0.00001837216,0.0002736592,0.9919802,0.00002301425,0.004526544,0.000003772224],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9835941,0.008558628,0.002646695,0.0002016057,0.0001006608,0.00005039018,0.0007848071,0.0002109073,0.003852294],"genre_scores_gemma":[0.9915112,0.002131116,0.001493791,0.00009053098,0.00002537657,0.00003948956,0.001061118,0.0000240624,0.003623187],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001803195,"threshold_uncertainty_score":0.006032288,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0323722216305142,"score_gpt":0.2480153592734698,"score_spread":0.2156431376429556,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}