{"id":"W4366831749","doi":"10.1093/rheumatology/kead104.176","title":"P135 Efficacy and safety of upadacitinib in TNFi inadequate responders with rheumatoid arthritis from three Phase 3 clinical trials","year":2023,"lang":"en","type":"article","venue":"Lara D. Veeken","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Medac; Celgene; Biogen; Gilead Sciences; Amgen; Pfizer; Eli Lilly and Company","keywords":"Medicine; Rheumatoid arthritis; Adalimumab; Internal medicine; Population; Imputation (statistics); Clinical trial; Missing data","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01109194,0.0009683214,0.002487803,0.0005189417,0.0004726937,0.00159398,0.0006810672,0.0009626183,0.00551446],"category_scores_gemma":[0.008835971,0.000343782,0.007103975,0.0009643437,0.0004950641,0.0007174977,0.0006213241,0.001652392,0.0006295372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007027765,"about_ca_system_score_gemma":0.002178164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005835615,"about_ca_topic_score_gemma":0.001717568,"domain_scores_codex":[0.9955264,0.002684945,0.000609375,0.0003581712,0.0005526149,0.0002684491],"domain_scores_gemma":[0.9945938,0.002386981,0.001350135,0.0005176343,0.0007602051,0.0003912007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7339573,0.003162754,0.01276338,0.01042081,0.04256752,0.0003739423,0.0002448111,0.003116392,0.00960033,0.0005219878,0.01359778,0.169673],"study_design_scores_gemma":[0.6489378,0.1459439,0.07165658,0.001883013,0.08225135,0.001280314,0.0002320289,0.004122038,0.00751292,0.002236138,0.03374865,0.000195328],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8719566,0.06912923,0.007793137,0.002653531,0.0008311911,0.01393436,0.02023811,0.0005381713,0.01292568],"genre_scores_gemma":[0.9677699,0.007833106,0.003719063,0.001507989,0.000276345,0.006751948,0.01019985,0.00006658866,0.001875247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01109194,"threshold_uncertainty_score":0.05866045,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08433469828185793,"score_gpt":0.3914484251973744,"score_spread":0.3071137269155165,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}