{"id":"W4366960435","doi":"10.2139/ssrn.4418841","title":"Small Gtpases Control Macropinocytosis of Amyloid Precursor Protein and Cleavage to Amyloid-Β","year":2023,"lang":"en","type":"preprint","venue":"SSRN Electronic Journal","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Pinocytosis; Cleavage (geology); GTPase; Chemistry; Amyloid precursor protein; Amyloid (mycology); Cell biology; Biochemistry; Biology; Endocytosis; Medicine; Internal medicine; Cell; Alzheimer's disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002379284,0.0003620341,0.0003796083,0.0002925093,0.0002486892,0.0009922269,0.0001631403,0.000438552,0.002422491],"category_scores_gemma":[0.0005647802,0.0001850902,0.0002535289,0.000228508,0.0002568406,0.0005694716,0.0003546882,0.0004044982,0.001290559],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004427162,"about_ca_system_score_gemma":0.0002386523,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004580705,"about_ca_topic_score_gemma":0.0005242987,"domain_scores_codex":[0.9998662,0.00001637556,0.000009310382,0.00003277126,0.00003898872,0.00003634048],"domain_scores_gemma":[0.9998765,0.00003754768,0.00002718841,0.00001468003,0.00002103744,0.00002310366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001487504,0.00007085063,0.002114672,0.0001620238,0.00003758695,0.0004648915,0.0001745553,0.001873801,0.947282,0.01379062,0.003321123,0.02922032],"study_design_scores_gemma":[0.0002203039,0.0003021573,0.04048259,0.0000383014,0.00006506297,0.0009184626,0.0004349719,0.03381273,0.8851815,0.01735138,0.02114346,0.00004899941],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9708057,0.005588377,0.006311052,0.0009629233,0.0003105011,0.00002155504,0.000535752,0.0005203471,0.0149439],"genre_scores_gemma":[0.9871184,0.0017092,0.002472456,0.00009349645,0.00005119978,0.00001606645,0.0005135384,0.0000947282,0.007930961],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002422491,"threshold_uncertainty_score":0.008104026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03454085207259772,"score_gpt":0.3032961476334759,"score_spread":0.2687552955608782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}