{"id":"W4366975701","doi":"10.3390/microorganisms11051095","title":"Viral Fitness of Baloxavir-Resistant Recombinant Influenza B/Victoria- and B/Yamagata-like Viruses Harboring the I38T PA Change, In Vitro, Ex Vivo and in Guinea Pigs","year":2023,"lang":"en","type":"article","venue":"Microorganisms","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Virology; Ex vivo; Biology; Viral replication; Virus; Recombinant DNA; In vitro; Guinea pig; In vivo; Mutant; Microbiology; Molecular biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009430094,0.000315874,0.0006591558,0.0004676468,0.000144987,0.00005423546,0.0002298709,0.0001409625,0.00004401245],"category_scores_gemma":[0.0003918923,0.0002334129,0.00005263854,0.0009398805,0.0003744796,0.000204184,0.0005760811,0.0004348422,0.00002344564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001460199,"about_ca_system_score_gemma":0.0000884829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002066299,"about_ca_topic_score_gemma":0.0007635398,"domain_scores_codex":[0.9976964,0.0001480975,0.0006065434,0.000472821,0.0004028582,0.0006732913],"domain_scores_gemma":[0.9988793,0.0002923081,0.000124101,0.0004640425,0.0001204084,0.0001198703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000880217,0.00009753392,0.046487,0.0003121092,0.00005735507,0.0001564299,0.004649681,0.000001136193,0.9456086,0.00006462804,0.0004002306,0.001285063],"study_design_scores_gemma":[0.005697717,0.0003416721,0.4905499,0.0005514697,0.00006559717,0.00002009202,0.001663527,0.0001248183,0.4741217,0.0002106093,0.02624481,0.0004081185],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947252,0.003197195,0.000001444559,0.0007017973,0.0002444682,0.000873314,0.00008710545,0.00006186891,0.0001076275],"genre_scores_gemma":[0.9971486,0.001088387,0.0001850102,0.001067911,0.0001263807,0.0001062223,0.00001044428,0.00006523335,0.0002018084],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.471487,"threshold_uncertainty_score":0.9518302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08104027044498001,"score_gpt":0.3530532248861882,"score_spread":0.2720129544412082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}