{"id":"W4366975701","doi":"10.3390/microorganisms11051095","title":"Viral Fitness of Baloxavir-Resistant Recombinant Influenza B/Victoria- and B/Yamagata-like Viruses Harboring the I38T PA Change, In Vitro, Ex Vivo and in Guinea Pigs","year":2023,"lang":"en","type":"article","venue":"Microorganisms","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Virology; Ex vivo; Biology; Viral replication; Virus; Recombinant DNA; In vitro; Guinea pig; In vivo; Mutant; Microbiology; Molecular biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000176266,0.0002750349,0.0001863455,0.0001086173,0.0001013287,0.0002199314,0.0001739016,0.0002657593,0.0007437468],"category_scores_gemma":[0.0001638661,0.0001074553,0.0002036595,0.00008135648,0.0001327128,0.0001639727,0.0001504311,0.0004771572,0.0002589135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001900888,"about_ca_system_score_gemma":0.0001088802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002084156,"about_ca_topic_score_gemma":0.001307263,"domain_scores_codex":[0.9998285,0.00004466573,0.00002213219,0.00004225931,0.00002728604,0.00003513264],"domain_scores_gemma":[0.9999051,0.00003184111,0.00002024197,0.00001288412,0.00001343246,0.00001641394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001129999,0.00002658815,0.0006186452,0.00002257398,0.000004996958,0.00002647616,0.00002947706,0.00007445327,0.9985019,0.00002200394,0.00001901587,0.0005409294],"study_design_scores_gemma":[0.00002224799,0.002652586,0.02394923,0.00001322113,0.00003809801,0.000447532,0.0001853185,0.002957284,0.96864,0.00004111752,0.001036008,0.00001731268],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991226,0.000171057,0.0002437355,0.00000961043,0.00000472203,0.000008047878,0.0001676569,0.000005185393,0.0002673737],"genre_scores_gemma":[0.9974215,0.000181198,0.000814296,0.00002044671,0.000003218377,0.00002406579,0.0005917824,0.000008147064,0.0009353367],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002084156,"threshold_uncertainty_score":0.004144013,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08104027044498001,"score_gpt":0.3530532248861882,"score_spread":0.2720129544412082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}