{"id":"W4366977150","doi":"10.1016/j.vaccine.2023.04.036","title":"A Phase III, multicenter, randomized, double-blind, active comparator-controlled study to evaluate the safety, tolerability, and immunogenicity of V114 compared with PCV13 in healthy infants (PNEU-PED-EU-1)","year":2023,"lang":"en","type":"article","venue":"Vaccine","topic":"Pneumonia and Respiratory Infections","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Medicine; Pneumococcal conjugate vaccine; Confidence interval; Toddler; Serotype; Adverse effect; Immunogenicity; Vaccination; Tolerability; Randomized controlled trial; Neutralizing antibody; Seroconversion; Pediatrics; Streptococcus pneumoniae; Internal medicine; Antibody; Immunology; Microbiology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002718766,0.00175801,0.003908265,0.000427104,0.0005485864,0.0009500268,0.001330153,0.002295654,0.003891616],"category_scores_gemma":[0.002538446,0.0007678369,0.001439013,0.000485715,0.001397033,0.001073268,0.0004293032,0.00307335,0.0006579486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008420355,"about_ca_system_score_gemma":0.00190196,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001046462,"about_ca_topic_score_gemma":0.002004385,"domain_scores_codex":[0.9989259,0.0005825907,0.00005573683,0.00020698,0.00009045687,0.0001382663],"domain_scores_gemma":[0.9985242,0.0004721228,0.0003356957,0.0001445056,0.0001329337,0.0003905538],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.971451,0.0129282,0.0004276292,0.0004113164,0.0007381241,0.00002607023,0.00004538705,0.0002073713,0.003929316,0.0001054037,0.0004170121,0.009313072],"study_design_scores_gemma":[0.9084836,0.0896688,0.0007639574,0.00001647006,0.0002029167,0.0000185936,0.00001123388,0.0001670788,0.0003803557,0.0000553857,0.0002245985,0.000006969341],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812692,0.003448263,0.001977782,0.0004304169,0.0005486852,0.009517346,0.001272681,0.0001600231,0.001375609],"genre_scores_gemma":[0.9771324,0.00201792,0.004401022,0.001334254,0.0004442868,0.01086327,0.001399854,0.00004721435,0.002359854],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003908265,"threshold_uncertainty_score":0.01437837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04634069637916249,"score_gpt":0.380294378049284,"score_spread":0.3339536816701215,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}