{"id":"W4366978224","doi":"10.1016/j.biochi.2023.04.015","title":"CogiTx1: A novel subtilisin A inhibitor isolated from the sea anemone Condylactis gigantea belonging to the defensin 4 protein family","year":2023,"lang":"en","type":"article","venue":"Biochimie","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"German Academic Exchange Service; Bundesministerium für Bildung, Wissenschaft, Forschung und Technologie; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; Deutscher Akademischer Austauschdienst; International Union of Biochemistry and Molecular Biology","keywords":"Sea anemone; Subtilisin; Anemone; Defensin; Biology; Botany; Biochemistry; Gene; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007726324,0.0008337414,0.000465864,0.0003350814,0.0002453648,0.000379462,0.0002733365,0.0003691648,0.0007566563],"category_scores_gemma":[0.00008961642,0.000124066,0.0002999642,0.0002349879,0.0002081858,0.0001455304,0.0002155321,0.0004757965,0.0002611106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003610068,"about_ca_system_score_gemma":0.0003211256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001008616,"about_ca_topic_score_gemma":0.001047912,"domain_scores_codex":[0.9999511,0.000003691481,0.000004202381,0.00001336401,0.00001316342,0.00001448903],"domain_scores_gemma":[0.9999331,0.000006917312,0.00001455151,0.000003442845,0.000009570292,0.00003245781],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001788782,0.00002329731,0.0004250402,0.00006484616,0.00001204998,0.0001564605,0.00001112063,0.00007449739,0.996393,0.00002941351,0.000108013,0.002523395],"study_design_scores_gemma":[0.00008060069,0.0006142279,0.01174387,0.00001845458,0.00007061037,0.001794362,0.00004074415,0.0009677544,0.9733219,0.00004044953,0.01129175,0.00001520658],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859362,0.006353615,0.003826476,0.0001640542,0.0001034179,0.00009884487,0.001457182,0.0002162723,0.001843914],"genre_scores_gemma":[0.9772543,0.003251528,0.007295093,0.0002529566,0.0000599606,0.00005126844,0.006785451,0.00005442953,0.004995088],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001008616,"threshold_uncertainty_score":0.002619326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01920316238120228,"score_gpt":0.2220997254325505,"score_spread":0.2028965630513482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}