{"id":"W4366982937","doi":"10.1172/jci.insight.170068","title":"Multiancestry sex-stratified genomic associations with HIV viral load and controller status from the ICGH","year":2023,"lang":"en","type":"article","venue":"JCI Insight","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Public Health Agency of Canada","funders":"National Institute of Allergy and Infectious Diseases; NIH Office of the Director; National Institutes of Health; Public Health Agency; Public Health Agency of Canada","keywords":"Biology; Human leukocyte antigen; Viral load; Genetics; Genome-wide association study; Epigenetics; Genetic association; Gene; Single-nucleotide polymorphism; Genotype; Virus; Antigen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001168546,0.0003633759,0.0003960112,0.0009561499,0.0004682055,0.0008471527,0.0003114782,0.0003160257,0.005431305],"category_scores_gemma":[0.002816957,0.0001598886,0.0007390679,0.001086857,0.0003108508,0.000232577,0.0005172138,0.0005859933,0.0003242142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002138135,"about_ca_system_score_gemma":0.000268615,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003300742,"about_ca_topic_score_gemma":0.0048069,"domain_scores_codex":[0.9989102,0.0003794508,0.00008289993,0.0003195357,0.0001586792,0.0001492707],"domain_scores_gemma":[0.9984395,0.0005439412,0.0003439552,0.0004097706,0.0001316436,0.0001312053],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006528355,0.00002390418,0.9680262,0.00005198605,0.0009015988,0.0003454781,0.0002773252,0.0003469988,0.008636566,0.0003758407,0.0008111832,0.01955022],"study_design_scores_gemma":[0.00002798588,0.000162368,0.9909169,0.00002213688,0.000400211,0.001484746,0.000167013,0.001616654,0.001860289,0.0007365606,0.002589577,0.00001561391],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888771,0.001069331,0.004986553,0.0001353529,0.00003262451,0.00003382817,0.00243108,0.0000792723,0.00235469],"genre_scores_gemma":[0.9966933,0.0001146357,0.001350765,0.00004861563,0.00001592385,0.00002644638,0.001192889,0.00003034783,0.0005270462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005431305,"threshold_uncertainty_score":0.01816946,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01929200006639292,"score_gpt":0.2533176959936038,"score_spread":0.2340256959272108,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}