{"id":"W4366982970","doi":"10.1002/advs.202204378","title":"Intracellular Adhesion Molecule‐1 Improves Responsiveness to Immune Checkpoint Inhibitor by Activating CD8<sup>+</sup> T Cells","year":2023,"lang":"en","type":"article","venue":"Advanced Science","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nexen (Canada)","funders":"Samsung Medical Center, Sungkyunkwan University; Samsung; Korea Health Industry Development Institute; National Research Foundation of Korea; Ministry of Science and ICT, South Korea; National Research Foundation","keywords":"Cancer research; Cytotoxic T cell; Intracellular; Immune system; CD8; Chemokine; Lung cancer; ICAM-1; Intercellular adhesion molecule; Chemistry; Immunotherapy; Medicine; Immunology; Cell biology; Biology; Cell adhesion; Cell; Internal medicine; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001090924,0.0002289358,0.0002921927,0.0003297072,0.0003853555,0.00006465981,0.000358364,0.00007284435,0.00003567347],"category_scores_gemma":[0.0005360483,0.0002010527,0.0001084726,0.002784495,0.00036283,0.0004148544,0.000192527,0.0002184321,0.0001002481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003054107,"about_ca_system_score_gemma":0.0003481123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004991733,"about_ca_topic_score_gemma":8.082271e-7,"domain_scores_codex":[0.99749,0.00004552797,0.0004205103,0.0006980299,0.0006773617,0.0006685943],"domain_scores_gemma":[0.9987254,0.0001288151,0.0001324399,0.0005674895,0.0002000295,0.0002458084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001255888,0.00004396036,0.00001817597,0.00003847094,0.000009777371,0.00002042674,0.000863864,0.0002659695,0.9381697,0.000005394952,0.0001916503,0.05911675],"study_design_scores_gemma":[0.001145126,0.0005424888,0.0009426523,0.0002895187,0.000008008374,0.000009993796,0.001442997,0.001515557,0.9836036,0.00002152999,0.01022807,0.0002504517],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959421,0.0005157285,0.0006725418,0.001485447,0.0003323746,0.0006560693,0.00001058457,0.0001889829,0.000196128],"genre_scores_gemma":[0.9947283,0.0001527026,0.002808866,0.0005623755,0.00007533538,0.00005140203,0.00001171358,0.00003477894,0.001574503],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0588663,"threshold_uncertainty_score":0.8198691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01060169171938623,"score_gpt":0.2783115884234496,"score_spread":0.2677098967040633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}