{"id":"W4366982970","doi":"10.1002/advs.202204378","title":"Intracellular Adhesion Molecule‐1 Improves Responsiveness to Immune Checkpoint Inhibitor by Activating CD8<sup>+</sup> T Cells","year":2023,"lang":"en","type":"article","venue":"Advanced Science","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nexen (Canada)","funders":"Samsung Medical Center, Sungkyunkwan University; Samsung; Korea Health Industry Development Institute; National Research Foundation of Korea; Ministry of Science and ICT, South Korea; National Research Foundation","keywords":"Cancer research; Cytotoxic T cell; Intracellular; Immune system; CD8; Chemokine; Lung cancer; ICAM-1; Intercellular adhesion molecule; Chemistry; Immunotherapy; Medicine; Immunology; Cell biology; Biology; Cell adhesion; Cell; Internal medicine; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006632481,0.0002442421,0.0002193941,0.000142608,0.00005815806,0.0002002321,0.0001235472,0.0001417556,0.001486739],"category_scores_gemma":[0.00007163818,0.00006905299,0.0001344773,0.00007093804,0.00009162768,0.0001071193,0.00009437267,0.0005569254,0.0002624199],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009808079,"about_ca_system_score_gemma":0.0001184878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001002332,"about_ca_topic_score_gemma":0.0002321776,"domain_scores_codex":[0.9999561,0.000006701683,0.000004323653,0.000005607894,0.000009318228,0.00001798669],"domain_scores_gemma":[0.9999746,0.000004073424,0.000006925798,0.000002647124,0.000002472724,0.0000092486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001305344,0.0007211508,0.0009712719,0.00007363135,0.00001865577,0.0000555164,0.00001052592,0.0002475537,0.9640026,0.0001496557,0.000552498,0.03189161],"study_design_scores_gemma":[0.0004930518,0.01155098,0.02112947,0.00001403735,0.0000937508,0.000680093,0.00002786025,0.002213558,0.9550493,0.0001726237,0.008566867,0.000008491155],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963426,0.001103456,0.0006833585,0.000129374,0.00005810062,0.00003206483,0.0001185818,0.00008502238,0.001447491],"genre_scores_gemma":[0.996039,0.0006839932,0.001010922,0.0001059473,0.0000362615,0.00003947072,0.000320095,0.000009788153,0.001754447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001486739,"threshold_uncertainty_score":0.00497365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01060169171938623,"score_gpt":0.2783115884234496,"score_spread":0.2677098967040633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}