{"id":"W4366983093","doi":"10.1124/dmd.123.001267","title":"6-Formylindolo[3,2-b]carbazole Protects Against Angiotensin II-Induced Cellular Hypertrophy through the Induction of Cytochrome P450 1A1 and Its Associated 19(S)-HETE Metabolite In Vitro","year":2023,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Eicosanoids and Hypertension Pharmacology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Aryl hydrocarbon receptor; Chemistry; Cytochrome P450; Angiotensin II; Hydroxyeicosatetraenoic acid; Metabolite; Internal medicine; Endocrinology; Arachidonic acid; Enzyme; Receptor; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001909799,0.0003418066,0.0004416407,0.0003033124,0.0003157468,0.0002276358,0.0003379551,0.0003612286,0.002406073],"category_scores_gemma":[0.000192154,0.0002289813,0.0002544854,0.0002169011,0.0003543108,0.000253657,0.0001479407,0.001123901,0.0005106372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002901664,"about_ca_system_score_gemma":0.0004687818,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003162944,"about_ca_topic_score_gemma":0.005831507,"domain_scores_codex":[0.9998643,0.00002401409,0.000007359311,0.00001518527,0.000021198,0.00006782512],"domain_scores_gemma":[0.999846,0.00002598922,0.00003007652,0.00002669152,0.00001816196,0.00005316287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002226816,0.0003601692,0.0003446086,0.00002855281,0.00001283869,0.00009460608,0.00003315945,0.00005930882,0.9934937,0.00008412546,0.0001338752,0.003128343],"study_design_scores_gemma":[0.0003490123,0.005684566,0.01475322,0.000007593142,0.00005192877,0.0002372203,0.00006731376,0.0008799719,0.9759879,0.00005786177,0.001912555,0.00001082546],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995791,0.001350751,0.001219534,0.0001678799,0.00007423995,0.00002531008,0.0001409364,0.0001317779,0.001098591],"genre_scores_gemma":[0.9960734,0.0007822534,0.0005783042,0.00005981317,0.00004338096,0.00002238007,0.0003606394,0.00001700825,0.002063021],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003162944,"threshold_uncertainty_score":0.008049071,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01468256465282463,"score_gpt":0.2465512922408624,"score_spread":0.2318687275880378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}