{"id":"W4366983093","doi":"10.1124/dmd.123.001267","title":"6-Formylindolo[3,2-b]carbazole Protects Against Angiotensin II-Induced Cellular Hypertrophy through the Induction of Cytochrome P450 1A1 and Its Associated 19(S)-HETE Metabolite In Vitro","year":2023,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Eicosanoids and Hypertension Pharmacology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Aryl hydrocarbon receptor; Chemistry; Cytochrome P450; Angiotensin II; Hydroxyeicosatetraenoic acid; Metabolite; Internal medicine; Endocrinology; Arachidonic acid; Enzyme; Receptor; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004039941,0.000230479,0.0003838073,0.0001326333,0.0002583445,0.00002425601,0.0001076843,0.0002243835,0.000002749991],"category_scores_gemma":[0.00007314425,0.0001766632,0.00009970889,0.0003977353,0.00009248478,0.00003425961,0.0001454554,0.0002004528,0.000002460572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009722791,"about_ca_system_score_gemma":0.00004494634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007883932,"about_ca_topic_score_gemma":0.000009993881,"domain_scores_codex":[0.9984823,0.0002558012,0.0003355425,0.0004166338,0.0001782794,0.0003314234],"domain_scores_gemma":[0.9993938,0.00002428783,0.0001712264,0.0002026503,0.0001235525,0.00008451003],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002300282,0.00008482697,0.00001458291,0.0000225941,0.00007149131,0.000009457625,0.0004583977,0.00003807042,0.9970539,0.0001259417,0.0001349131,0.001755823],"study_design_scores_gemma":[0.001750114,0.00007958426,0.01645682,0.00001680887,0.0001123116,0.0000124913,0.0002000856,0.0008701199,0.9778004,0.0002277186,0.002246811,0.0002267325],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922732,0.006012232,0.00003221284,0.0007247452,0.0001871414,0.0005815163,0.0001057303,0.00002807999,0.00005519835],"genre_scores_gemma":[0.9966309,0.001736648,0.00006678542,0.0007241931,0.0001759845,0.0000706479,0.0004741086,0.00002683038,0.00009390224],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01925347,"threshold_uncertainty_score":0.7204115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01468256465282463,"score_gpt":0.2465512922408624,"score_spread":0.2318687275880378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}