{"id":"W4366984381","doi":"10.1038/s41598-023-33869-7","title":"Neuropathological signatures revealed by transcriptomic and proteomic analysis in Pten-deficient mouse models","year":2023,"lang":"en","type":"article","venue":"Scientific Reports","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Chinese University of Hong Kong","keywords":"PTEN; Biology; Knockout mouse; Transcriptome; Gene; Cell biology; Neuroscience; PI3K/AKT/mTOR pathway; Gene expression; Genetics; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000134856,0.0005717542,0.0002580945,0.001477895,0.0001919584,0.0003524413,0.0001636383,0.0002887333,0.0008728469],"category_scores_gemma":[0.0001322353,0.0001862544,0.0003551274,0.0004731427,0.0002747712,0.0001705087,0.0002419782,0.0004066559,0.0002632368],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001948269,"about_ca_system_score_gemma":0.0001514816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006005805,"about_ca_topic_score_gemma":0.0009421423,"domain_scores_codex":[0.9998649,0.000009073184,0.00001296997,0.00003876089,0.00004775201,0.00002647605],"domain_scores_gemma":[0.9998518,0.00001323491,0.00006666268,0.000008554725,0.00001807917,0.00004161694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002037425,0.00001813341,0.001431567,0.0000416873,0.00002595921,0.0003068277,0.00001584283,0.00007093887,0.9967892,0.00006230998,0.00004603103,0.0009877826],"study_design_scores_gemma":[0.00004691796,0.0006020247,0.2526708,0.00004491774,0.0003256075,0.00639943,0.000228154,0.002984478,0.7325384,0.0005885063,0.003532313,0.00003838883],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921882,0.000856624,0.003193373,0.00005342875,0.000016935,0.00003103155,0.002820925,0.0001489522,0.0006904581],"genre_scores_gemma":[0.9863229,0.00171402,0.004807391,0.00009263575,0.000009692239,0.0001138492,0.004250265,0.00006846368,0.002620887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001477895,"threshold_uncertainty_score":0.002919972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0128977059883808,"score_gpt":0.2474729400339924,"score_spread":0.2345752340456116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}