{"id":"W4366989843","doi":"10.1038/s41423-023-01020-1","title":"Culture-expanded mesenchymal stromal cell therapy: does it work in knee osteoarthritis? A pathway to clinical success","year":2023,"lang":"en","type":"review","venue":"Cellular and Molecular Immunology","topic":"Mesenchymal stem cell research","field":"Medicine","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"Research Canada; Toronto Rehabilitation Institute; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Medicine; Osteoarthritis; Mesenchymal stem cell; Clinical trial; Randomized controlled trial; Disease; Cartilage; Internal medicine; Biomarker; Oncology; Bioinformatics; Physical therapy; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01246742,0.0003751043,0.001449697,0.0006237731,0.0002717232,0.002134528,0.0006653601,0.001249618,0.002920777],"category_scores_gemma":[0.01344479,0.0001292562,0.001007149,0.0006846501,0.001750861,0.001735318,0.0006198544,0.001716798,0.0005966242],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007928435,"about_ca_system_score_gemma":0.001481853,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007329708,"about_ca_topic_score_gemma":0.001910348,"domain_scores_codex":[0.9951631,0.002926647,0.000500931,0.0003194571,0.0009434416,0.0001462936],"domain_scores_gemma":[0.9905086,0.005189269,0.001517344,0.000811381,0.001418351,0.0005551955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.003620878,0.0007143574,0.007849853,0.006387625,0.0006188011,0.0002049827,0.0005747341,0.000527545,0.01549659,0.004670032,0.004538801,0.9547958],"study_design_scores_gemma":[0.01311902,0.1562463,0.1705632,0.05870805,0.01229464,0.004672839,0.005381675,0.007135438,0.09412171,0.06485987,0.4122142,0.0006829249],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.09669203,0.8487074,0.005080677,0.04246063,0.001738576,0.000287454,0.0002230525,0.00006908923,0.004741044],"genre_scores_gemma":[0.5487474,0.3914251,0.01779204,0.03256803,0.005972437,0.0004104935,0.0003082745,0.00007885955,0.002697336],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01246742,"threshold_uncertainty_score":0.06593478,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05966635356969095,"score_gpt":0.3755462747648136,"score_spread":0.3158799211951226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}