{"id":"W4366997708","doi":"10.1200/jco.22.02524","title":"Long-Term Outcomes and Molecular Correlates of Sotorasib Efficacy in Patients With Pretreated <i>KRAS</i> G12C-Mutated Non–Small-Cell Lung Cancer: 2-Year Analysis of CodeBreaK 100","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":149,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Daiichi Sankyo Europe; National Cancer Institute; Genentech; European Society for Medical Oncology; Shanghai Jiao Tong University; Revolution Medicines; Jiangsu Hengrui Medicine; Calithera Biosciences; BeiGene; Mirati Therapeutics; McGill University; Moderna; Memorial Sloan-Kettering Cancer Center; Amgen; Pfizer; AstraZeneca; Eli Lilly and Company","keywords":"Medicine; KRAS; Clinical endpoint; Tolerability; Internal medicine; Clinical trial; Lung cancer; Oncology; Discontinuation; Phases of clinical research; Surrogate endpoint; Cancer; Adverse effect; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004923252,0.0001605635,0.001853532,0.0004971076,0.00001903905,0.000004637352,0.00009717089,0.0002160391,0.00005663327],"category_scores_gemma":[0.0003382696,0.0001023108,0.0003356247,0.0009958808,0.0001555771,0.00005731127,0.00003629472,0.0003319875,0.000001018178],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001344449,"about_ca_system_score_gemma":0.00081189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001784717,"about_ca_topic_score_gemma":0.0001740716,"domain_scores_codex":[0.9974908,0.0001494265,0.001667466,0.0001991278,0.0003017166,0.0001914753],"domain_scores_gemma":[0.9966319,0.000935056,0.001508845,0.0001732868,0.0005496411,0.0002012561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002733191,0.002527487,0.9837051,0.00008332862,0.00614132,0.0002503576,0.0003110893,0.0009501102,0.00006800479,0.000001981348,0.0001048865,0.003123121],"study_design_scores_gemma":[0.02156975,0.004628719,0.9619693,0.0002276401,0.01081843,0.000003116397,0.00005526238,0.0004723313,0.0001580955,0.00000249705,0.00001374032,0.00008109702],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984507,0.0002856728,0.00002928997,0.0003489014,0.0001994142,0.0004541466,0.00003305625,0.00000834926,0.0001904789],"genre_scores_gemma":[0.9988849,0.0004804892,0.000256035,0.0001454384,0.00001956951,0.000007912951,0.0000559282,0.00001841552,0.0001313135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02173581,"threshold_uncertainty_score":0.4172114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03039771911843098,"score_gpt":0.4310050438791679,"score_spread":0.400607324760737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}