{"id":"W4366997708","doi":"10.1200/jco.22.02524","title":"Long-Term Outcomes and Molecular Correlates of Sotorasib Efficacy in Patients With Pretreated <i>KRAS</i> G12C-Mutated Non–Small-Cell Lung Cancer: 2-Year Analysis of CodeBreaK 100","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":149,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Daiichi Sankyo Europe; National Cancer Institute; Genentech; European Society for Medical Oncology; Shanghai Jiao Tong University; Revolution Medicines; Jiangsu Hengrui Medicine; Calithera Biosciences; BeiGene; Mirati Therapeutics; McGill University; Moderna; Memorial Sloan-Kettering Cancer Center; Amgen; Pfizer; AstraZeneca; Eli Lilly and Company","keywords":"Medicine; KRAS; Clinical endpoint; Tolerability; Internal medicine; Clinical trial; Lung cancer; Oncology; Discontinuation; Phases of clinical research; Surrogate endpoint; Cancer; Adverse effect; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004264446,0.0004118538,0.0008149524,0.0004051883,0.0003747595,0.00117473,0.0004102092,0.0007226081,0.001552653],"category_scores_gemma":[0.003003646,0.0002286767,0.001314256,0.0005330901,0.0004983788,0.001226616,0.0005766011,0.001816344,0.0003960708],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008195676,"about_ca_system_score_gemma":0.0007692768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000597664,"about_ca_topic_score_gemma":0.001385834,"domain_scores_codex":[0.9990917,0.0003013872,0.00007864262,0.0001975984,0.0001670963,0.0001635427],"domain_scores_gemma":[0.9949759,0.001097081,0.002053317,0.0004457445,0.0004113754,0.001016646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2329821,0.004570013,0.6635376,0.0008217912,0.003578742,0.0003206172,0.0002355078,0.003837917,0.01755127,0.0002983993,0.003419852,0.06884611],"study_design_scores_gemma":[0.008068158,0.06468435,0.916464,0.0000747762,0.001629044,0.0004770782,0.0001165803,0.002580993,0.00261836,0.000299908,0.002907864,0.00007904888],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952656,0.001756477,0.0002388237,0.000112492,0.00002190703,0.00012888,0.001244322,0.00001563733,0.001215777],"genre_scores_gemma":[0.9943487,0.0003301387,0.000172042,0.000160065,0.00004433984,0.0001377438,0.004246435,0.000008584791,0.0005519587],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004264446,"threshold_uncertainty_score":0.02255279,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03039771911843098,"score_gpt":0.4310050438791679,"score_spread":0.400607324760737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}