{"id":"W4366998649","doi":"10.1093/pnasnexus/pgad085","title":"Developmental pyrethroid exposure causes a neurodevelopmental disorder phenotype in mice","year":2023,"lang":"en","type":"article","venue":"PNAS Nexus","topic":"Pesticide Exposure and Toxicity","field":"Agricultural and Biological Sciences","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Environmental Health Sciences; Canadian Institute for Advanced Research; National Institute of Mental Health; National Institute on Deafness and Other Communication Disorders; Yerkes National Primate Research Center, Emory University; National Institutes of Health","keywords":"Dopamine; Dopamine transporter; Medium spiny neuron; Dopamine Plasma Membrane Transport Proteins; Offspring; Neuroscience; Biology; Striatum; Pharmacology; Endocrinology; Pregnancy; Dopaminergic; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005526525,0.001193586,0.0004889491,0.002223196,0.0007728213,0.0008191215,0.001068461,0.001836277,0.005137217],"category_scores_gemma":[0.0003489048,0.0009323495,0.0009514866,0.0006068115,0.0009886444,0.0005610032,0.0007968575,0.002324748,0.00155614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001219137,"about_ca_system_score_gemma":0.000756377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002297903,"about_ca_topic_score_gemma":0.004026804,"domain_scores_codex":[0.9988698,0.0001376474,0.0001619054,0.0003813005,0.0002747341,0.0001745053],"domain_scores_gemma":[0.9990711,0.0001356969,0.0003872515,0.0001225526,0.00006381456,0.000219407],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000626275,0.0004506158,0.001267758,0.00009687599,0.00004810743,0.000650829,0.0001370647,0.0003119868,0.9918339,0.0009324416,0.0004539071,0.00319017],"study_design_scores_gemma":[0.0003829139,0.001566944,0.01897641,0.0001084722,0.0001266042,0.002277,0.0001930753,0.003551985,0.9582637,0.0008069169,0.01370041,0.0000456184],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9624618,0.00158021,0.01512351,0.001128312,0.0001447005,0.0004680585,0.01128191,0.001263984,0.006547573],"genre_scores_gemma":[0.9497491,0.002152686,0.01588523,0.0007893419,0.00005010967,0.001246366,0.00665277,0.0005554845,0.0229188],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005137217,"threshold_uncertainty_score":0.01718569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02424759915505014,"score_gpt":0.2277401252609931,"score_spread":0.203492526105943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}