{"id":"W4366998885","doi":"10.1186/s13046-023-02678-1","title":"MYC drives platinum resistant SCLC that is overcome by the dual PI3K-HDAC inhibitor fimepinostat","year":2023,"lang":"en","type":"article","venue":"Journal of Experimental & Clinical Cancer Research","topic":"Lung Cancer Research Studies","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"Cancer Council Victoria; State Government of Victoria; Australian Government; National Imaging Facility; Marshfield Clinic Research Foundation; Victorian Cancer Agency","keywords":"Cancer research; Platinum; Dual (grammatical number); Apoptosis; PI3K/AKT/mTOR pathway; Chemistry; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009932855,0.0002607693,0.0002759542,0.0002364704,0.0001370952,0.0003585045,0.0002375191,0.0002603256,0.001617759],"category_scores_gemma":[0.00009561091,0.0001097436,0.0002810999,0.0001778087,0.0002170031,0.000163279,0.0001593585,0.0007688408,0.0003536117],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000356722,"about_ca_system_score_gemma":0.0002630246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006575067,"about_ca_topic_score_gemma":0.001748118,"domain_scores_codex":[0.9998955,0.000009691432,0.000011053,0.0000180199,0.00004063342,0.00002506338],"domain_scores_gemma":[0.999931,0.0000142474,0.00002255166,0.000009623612,0.000005934382,0.00001669166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001170587,0.00008598404,0.0004415006,0.00004943561,0.00001039244,0.0001030511,0.0000114199,0.0001656321,0.9949548,0.0001558759,0.0002270328,0.003677718],"study_design_scores_gemma":[0.00004156067,0.0008078371,0.004718268,0.000009184861,0.00002585549,0.0006883357,0.0000214596,0.0017701,0.9876128,0.00004511102,0.004254478,0.000005069809],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941571,0.0009988953,0.001561373,0.000176187,0.00003395473,0.00004894133,0.0005667644,0.000198301,0.002258481],"genre_scores_gemma":[0.9958782,0.0006348504,0.001145257,0.00005285049,0.000005676407,0.00004280739,0.0005300169,0.00001834192,0.001691941],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001617759,"threshold_uncertainty_score":0.005411923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2693083482917267,"score_gpt":0.5712986221216317,"score_spread":0.301990273829905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}