{"id":"W4367040782","doi":"10.1038/s41418-023-01153-w","title":"Apoptotic cell death in disease—Current understanding of the NCCD 2023","year":2023,"lang":"en","type":"review","venue":"Cell Death and Differentiation","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":351,"is_retracted":false,"has_abstract":false,"ca_institutions":"Memorial University of Newfoundland; University of British Columbia; Sunnybrook Hospital; University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Office of Defense Programs; Beatson Institute for Cancer Research; Universitätsmedizin der Johannes Gutenberg-Universität Mainz; Cambridge Institute for Medical Research, University of Cambridge; Biotechnology and Biological Sciences Research Council; Medical Research Council; University of Texas MD Anderson Cancer Center; LabEx DEvweCAN; Université de Paris; Centre Léon Bérard; Rede de Química e Tecnologia; Cancer Center Amsterdam; National University Health System; Southern Medical University; Novo Nordisk Fonden; Amsterdam University Medical Centers; Karolinska Institutet; Associazione Italiana per la Ricerca sul Cancro; Universität Stuttgart; Karl-Franzens-Universität Graz; Université de Lyon; Julius-Maximilians-Universität Würzburg; Sorbonne Université; UK Dementia Research Institute; Soochow University; Stony Brook University; Université de Genève; Universidad de Oviedo; Thomas Jefferson University; Università degli Studi dell'Aquila; Medizinische Universität Graz; Peking Union Medical College; University of Bern; Universidad de Chile; Leukemia and Lymphoma Society; Universidade de Lisboa; Università Cattolica del Sacro Cuore; Board of the Swiss Federal Institutes of Technology; Centre National de la Recherche Scientifique; Oncode Institute; Università degli Studi dell'Insubria; University of Tokyo; Consejo Nacional de Investigaciones Científicas y Técnicas; Universiteit Gent; Weill Cornell Medical College; York University; State Key Laboratory of Radiation Medicine and Protection; City University of New York; Royal College of Surgeons in Ireland; Ligue Contre le Cancer; University of Leicester; Institut Gustave-Roussy; Yale University; Compagnia di San Paolo; Technische Universität Dresden; Universiteit van Amsterdam; Österreichischen Akademie der Wissenschaften; Institut Universitaire de France; University of South Australia; Directorate for Biological Sciences; National Center for Advancing Translational Sciences; University of Adelaide; Universitat Pompeu Fabra; Institut National de la Santé et de la Recherche Médicale; Johns Hopkins University; Agence Nationale de la Recherche; Faculty of Health and Medical Sciences, University of Western Australia; U.S. Department of Defense; Cancer Research UK; La Trobe University; National University of Singapore; University of Queensland; Chinese Academy of Sciences; Università degli Studi di Roma Tor Vergata; St. John's University; University of Southampton; Stand Up To Cancer; Universidade do Porto; Northwestern University; University of Glasgow; Chinese Academy of Medical Sciences; Sanofi; Università degli Studi di Milano; Buck Institute for Research on Aging; University of Washington; Queens College, City University of New York; Dipartimento di Medicina e Chirurgia, Università degli Studi di Milano-Bicocca; NYU Grossman School of Medicine; National Institute on Aging; University of Bath; Universität zu Köln; Università degli Studi di Padova; University of California, San Diego; Peter MacCallum Cancer Centre; Johns Hopkins Bloomberg School of Public Health; Laboratório Associado para a Química Verde; National Cancer Institute; KU Leuven; University of South Carolina; University of Michigan; St. Jude Children's Research Hospital; National Natural Science Foundation of China; Cincinnati Children's Hospital Medical Center; Cancer Research Institute; National Institutes of Health","keywords":"Apoptosis; Proteases; Programmed cell death; Context (archaeology); Biology; Homeostasis; Carcinogenesis; Disease; Caspase; Cell biology; Cell; Embryonic stem cell; Immunology; Neuroscience; Pathology; Medicine; Cancer; Genetics; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000849943,0.001131002,0.00159467,0.001790036,0.0003670443,0.001623767,0.001230722,0.00165641,0.003901848],"category_scores_gemma":[0.0006635035,0.0003089519,0.0003722528,0.002254348,0.0009686277,0.00179781,0.001219466,0.002711853,0.002519359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001348906,"about_ca_system_score_gemma":0.001720098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001616863,"about_ca_topic_score_gemma":0.003387676,"domain_scores_codex":[0.9998042,0.00002885026,0.00002516408,0.00003383305,0.00008192506,0.00002616942],"domain_scores_gemma":[0.9996605,0.0001204306,0.00003820677,0.00001101128,0.0001142879,0.00005559312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001352934,0.0000534638,0.0001085323,0.008613555,0.00004428358,0.0002034779,0.00003703576,0.0004249488,0.001804144,0.01049145,0.07519981,0.902884],"study_design_scores_gemma":[0.00001736593,0.00004784746,0.000261453,0.001597216,0.000043207,0.0006372639,0.00002449269,0.00009010552,0.0002815536,0.002752865,0.9942339,0.00001261429],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003356974,0.9980414,0.0001556958,0.0003896292,0.0004482334,0.000003031112,0.00001094792,0.000006412056,0.0009111202],"genre_scores_gemma":[0.0002952705,0.998285,0.0001660705,0.0002674822,0.0003497717,0.000004644898,0.00001889682,0.000001288086,0.0006115588],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003901848,"threshold_uncertainty_score":0.01305294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06108229677129954,"score_gpt":0.2900814479145407,"score_spread":0.2289991511432411,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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