{"id":"W4367040782","doi":"10.1038/s41418-023-01153-w","title":"Apoptotic cell death in disease—Current understanding of the NCCD 2023","year":2023,"lang":"en","type":"review","venue":"Cell Death and Differentiation","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":351,"is_retracted":false,"has_abstract":false,"ca_institutions":"Memorial University of Newfoundland; University of British Columbia; Sunnybrook Hospital; University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Office of Defense Programs; Beatson Institute for Cancer Research; Universitätsmedizin der Johannes Gutenberg-Universität Mainz; Cambridge Institute for Medical Research, University of Cambridge; Biotechnology and Biological Sciences Research Council; Medical Research Council; University of Texas MD Anderson Cancer Center; LabEx DEvweCAN; Université de Paris; Centre Léon Bérard; Rede de Química e Tecnologia; Cancer Center Amsterdam; National University Health System; Southern Medical University; Novo Nordisk Fonden; Amsterdam University Medical Centers; Karolinska Institutet; Associazione Italiana per la Ricerca sul Cancro; Universität Stuttgart; Karl-Franzens-Universität Graz; Université de Lyon; Julius-Maximilians-Universität Würzburg; Sorbonne Université; UK Dementia Research Institute; Soochow University; Stony Brook University; Université de Genève; Universidad de Oviedo; Thomas Jefferson University; Università degli Studi dell'Aquila; Medizinische Universität Graz; Peking Union Medical College; University of Bern; Universidad de Chile; Leukemia and Lymphoma Society; Universidade de Lisboa; Università Cattolica del Sacro Cuore; Board of the Swiss Federal Institutes of Technology; Centre National de la Recherche Scientifique; Oncode Institute; Università degli Studi dell'Insubria; University of Tokyo; Consejo Nacional de Investigaciones Científicas y Técnicas; Universiteit Gent; Weill Cornell Medical College; York University; State Key Laboratory of Radiation Medicine and Protection; City University of New York; Royal College of Surgeons in Ireland; Ligue Contre le Cancer; University of Leicester; Institut Gustave-Roussy; Yale University; Compagnia di San Paolo; Technische Universität Dresden; Universiteit van Amsterdam; Österreichischen Akademie der Wissenschaften; Institut Universitaire de France; University of South Australia; Directorate for Biological Sciences; National Center for Advancing Translational Sciences; University of Adelaide; Universitat Pompeu Fabra; Institut National de la Santé et de la Recherche Médicale; Johns Hopkins University; Agence Nationale de la Recherche; Faculty of Health and Medical Sciences, University of Western Australia; U.S. Department of Defense; Cancer Research UK; La Trobe University; National University of Singapore; University of Queensland; Chinese Academy of Sciences; Università degli Studi di Roma Tor Vergata; St. John's University; University of Southampton; Stand Up To Cancer; Universidade do Porto; Northwestern University; University of Glasgow; Chinese Academy of Medical Sciences; Sanofi; Università degli Studi di Milano; Buck Institute for Research on Aging; University of Washington; Queens College, City University of New York; Dipartimento di Medicina e Chirurgia, Università degli Studi di Milano-Bicocca; NYU Grossman School of Medicine; National Institute on Aging; University of Bath; Universität zu Köln; Università degli Studi di Padova; University of California, San Diego; Peter MacCallum Cancer Centre; Johns Hopkins Bloomberg School of Public Health; Laboratório Associado para a Química Verde; National Cancer Institute; KU Leuven; University of South Carolina; University of Michigan; St. Jude Children's Research Hospital; National Natural Science Foundation of China; Cincinnati Children's Hospital Medical Center; Cancer Research Institute; National Institutes of Health","keywords":"Apoptosis; Proteases; Programmed cell death; Context (archaeology); Biology; Homeostasis; Carcinogenesis; Disease; Caspase; Cell biology; Cell; Embryonic stem cell; Immunology; Neuroscience; Pathology; Medicine; Cancer; Genetics; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001311333,0.0002932016,0.0004580522,0.0001367554,0.00009179011,0.00003385021,0.0001634161,0.0002394196,0.000009817086],"category_scores_gemma":[0.00002055084,0.0002057543,0.0002879687,0.0001812524,0.00002615424,0.000004255467,0.0001682207,0.0001519228,0.000005547129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006675452,"about_ca_system_score_gemma":0.0001205164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001026745,"about_ca_topic_score_gemma":0.00001799962,"domain_scores_codex":[0.9986038,0.0001234394,0.0004370607,0.0004239304,0.0001818691,0.0002298867],"domain_scores_gemma":[0.9991857,0.00002992256,0.0003297269,0.0003367348,0.00002475888,0.0000931482],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003088158,0.002466698,0.01272182,0.2600768,0.0006882787,0.00002293352,0.0005973562,0.0005058724,0.01390864,0.01847101,0.00162915,0.6886027],"study_design_scores_gemma":[0.008598157,0.0009729776,0.07199997,0.04917232,0.01058826,0.00002007687,0.0004082212,0.007759802,0.006255542,0.02632475,0.811173,0.006726914],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.009044264,0.9871842,0.002037025,0.000005089858,0.000665424,0.0007791728,0.00007016907,0.00001064466,0.0002040513],"genre_scores_gemma":[0.06951379,0.9285073,0.0000147939,0.000003716394,0.0001248217,0.00003872667,0.0008597127,0.00004017877,0.000896988],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8095438,"threshold_uncertainty_score":0.8390418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06108229677129954,"score_gpt":0.2900814479145407,"score_spread":0.2289991511432411,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}