{"id":"W4367042630","doi":"10.1016/j.jacadv.2023.100309","title":"Homozygous Familial Hypercholesterolemia in Canada","year":2023,"lang":"en","type":"article","venue":"JACC Advances","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; University of Toronto; Western University; Université de Montréal; Hospital for Sick Children; Université du Québec à Chicoutimi; University of Ottawa; McGill University Health Centre; Providence Health Care Research Institute; University of British Columbia; Queen Elizabeth II Health Sciences Centre; Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Familial hypercholesterolemia; Ezetimibe; Medicine; Interquartile range; Internal medicine; Population; PCSK9; Gastroenterology; Plasmapheresis; Dyslipidemia; Pediatrics; Lipoprotein; Cholesterol; Disease; LDL receptor; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001762717,0.0000877288,0.0002511216,0.00006956763,0.00003516894,0.000005015976,0.00006171801,0.00003161607,0.000019001],"category_scores_gemma":[0.00004739333,0.00007285154,0.00005862216,0.0003640467,0.00001527556,0.00007482029,0.00002629329,0.0001558322,0.00004414927],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003011482,"about_ca_system_score_gemma":0.0008082174,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.6199442,"about_ca_topic_score_gemma":0.8519368,"domain_scores_codex":[0.9989715,0.00002740806,0.0001706282,0.0001956247,0.0003460595,0.000288809],"domain_scores_gemma":[0.9995574,0.0000251059,0.00002248493,0.0002655547,0.00002439805,0.000105001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0001157814,0.00003590787,0.1299114,0.0003387739,0.0000439405,0.002949146,0.0002174492,0.0005037529,0.0003916734,0.00003682991,0.002872948,0.8625824],"study_design_scores_gemma":[0.002341511,0.0001155114,0.720499,0.0001673634,0.00002774301,0.0002538901,0.001651644,0.0002684392,0.0005442382,0.0002596822,0.2736424,0.0002285844],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994326,0.001951229,0.00001731775,0.0006516707,0.000350961,0.0002550023,0.000008248308,0.00005578588,0.002383818],"genre_scores_gemma":[0.9970742,0.001196283,0.0001586122,0.0007432327,0.0002861788,0.00004297705,0.00001623637,0.00001520796,0.000466998],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8623539,"threshold_uncertainty_score":0.3825866,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01174568663502535,"score_gpt":0.2602204025706649,"score_spread":0.2484747159356396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}