{"id":"W4367042630","doi":"10.1016/j.jacadv.2023.100309","title":"Homozygous Familial Hypercholesterolemia in Canada","year":2023,"lang":"en","type":"article","venue":"JACC Advances","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; University of Toronto; Western University; Université de Montréal; Hospital for Sick Children; Université du Québec à Chicoutimi; University of Ottawa; McGill University Health Centre; Providence Health Care Research Institute; University of British Columbia; Queen Elizabeth II Health Sciences Centre; Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Familial hypercholesterolemia; Ezetimibe; Medicine; Interquartile range; Internal medicine; Population; PCSK9; Gastroenterology; Plasmapheresis; Dyslipidemia; Pediatrics; Lipoprotein; Cholesterol; Disease; LDL receptor; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003397221,0.000237585,0.00033288,0.0009064017,0.00305134,0.0008963297,0.0006024319,0.0003294346,0.004680721],"category_scores_gemma":[0.0009876357,0.0001832231,0.0002970757,0.00323857,0.0004390753,0.0001725201,0.0006518336,0.0005582141,0.0004847913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01570699,"about_ca_system_score_gemma":0.04645087,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9861932,"about_ca_topic_score_gemma":0.9905785,"domain_scores_codex":[0.9993483,0.00003689845,0.00003931216,0.0001194626,0.0002226278,0.0002332653],"domain_scores_gemma":[0.9987037,0.00005334206,0.0001826935,0.00003179871,0.0006200444,0.0004083586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001668809,0.00008549765,0.9501548,0.0001829489,0.00006684497,0.001418857,0.0008355434,0.0001677072,0.0007856401,0.0009494657,0.01957411,0.02561167],"study_design_scores_gemma":[0.00004695146,0.00004761594,0.984985,0.0001669913,0.00005505918,0.00123548,0.001378912,0.0003009489,0.0001284617,0.0002072113,0.01142535,0.00002207739],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9367536,0.005739049,0.000734813,0.003657768,0.0001420551,0.0003761459,0.02202472,0.00009955411,0.0304723],"genre_scores_gemma":[0.9842395,0.003675155,0.0006392848,0.001125658,0.00003904772,0.00009441842,0.005970866,0.00001877651,0.004197217],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01570699,"threshold_uncertainty_score":0.1139627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01174568663502535,"score_gpt":0.2602204025706649,"score_spread":0.2484747159356396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}