{"id":"W4367043316","doi":"10.1016/j.isci.2023.106762","title":"Reconstruction of a polyclonal ADCC antibody repertoire from an HIV-1 non-transmitting mother","year":2023,"lang":"en","type":"article","venue":"iScience","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Office of Research Infrastructure Programs, National Institutes of Health; National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute; Howard Hughes Medical Institute; National Agri-Food Biotechnology Institute; National Institutes of Health; National Research Council Canada; Fred Hutchinson Cancer Research Center","keywords":"Antibody-dependent cell-mediated cytotoxicity; Polyclonal antibodies; Monoclonal antibody; Immunology; Epitope; Antibody; Virology; Monoclonal; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001811926,0.00006930767,0.0001128904,0.00009338636,0.0001643389,0.000009615283,0.0001732631,0.00006416994,0.0005104597],"category_scores_gemma":[0.00003433036,0.00005438817,0.00004005219,0.0002739623,0.0003536387,0.0001345755,0.00003146165,0.00009207041,0.001065357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001359336,"about_ca_system_score_gemma":0.00007141926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005700759,"about_ca_topic_score_gemma":0.00003778476,"domain_scores_codex":[0.9992298,0.00006308306,0.000136091,0.0002576346,0.00005112062,0.0002622845],"domain_scores_gemma":[0.9996383,0.00006496336,0.00004370429,0.0001961259,0.00002987702,0.00002708587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00003329221,0.00004762561,0.05051767,0.000003105042,0.00002400663,0.00001019496,0.0006544992,0.000004600011,0.8735155,0.00002542333,0.0002388548,0.07492526],"study_design_scores_gemma":[0.001640019,0.0004729854,0.5412493,0.0001248363,0.00002081409,0.000103406,0.001498529,0.0005470011,0.4487781,0.0004141589,0.004915786,0.0002351239],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973587,0.0002977006,0.000292787,0.0002860738,0.0002190594,0.00008833721,0.0001606086,0.00004910763,0.001247662],"genre_scores_gemma":[0.9979485,0.00004089065,0.0003129848,0.0000216432,0.00001756697,0.000006283648,0.0001426424,0.000005182488,0.001504265],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4907316,"threshold_uncertainty_score":0.9997124,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01439907814391767,"score_gpt":0.2943775131103396,"score_spread":0.2799784349664219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}