{"id":"W4367047765","doi":"10.1158/2159-8290.cd-22-1013","title":"Splicing Factor SRSF1 Promotes Pancreatitis and KRASG12D-Mediated Pancreatic Cancer","year":2023,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Child Health and Human Development; National Cancer Institute; National Institutes of Health; Zhejiang University; Cold Spring Harbor Laboratory; Hebrew University of Jerusalem; Government of Ontario; Lustgarten Foundation; St. Giles Foundation","keywords":"Pancreatitis; Pancreatic cancer; RNA splicing; Cancer research; Splicing factor; Cancer; Biology; Computational biology; Medicine; Bioinformatics; Genetics; Internal medicine; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008948547,0.0001809109,0.0002098367,0.00006961564,0.0001139254,0.00009855609,0.0001333091,0.0001005838,0.00005498332],"category_scores_gemma":[0.0001130191,0.0001560528,0.00006002175,0.0002282704,0.00009636569,0.00002206569,0.0001409835,0.0001073841,0.00002034588],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000417604,"about_ca_system_score_gemma":0.0001883791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00140891,"about_ca_topic_score_gemma":0.0005895775,"domain_scores_codex":[0.9987367,0.00004075918,0.0001616927,0.000419562,0.000179206,0.0004621293],"domain_scores_gemma":[0.9994617,0.00004067267,0.00005524403,0.0002480603,0.00004848853,0.0001458334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00005314773,0.0000107387,0.1248477,0.0001054639,0.000113523,0.00001448455,0.00007215146,0.00003441136,0.8670191,0.00001703049,0.002182228,0.00552994],"study_design_scores_gemma":[0.001976281,0.0004443527,0.4946882,0.0005406297,0.00009878017,0.00001869226,0.0004262324,0.001743869,0.4847174,0.0001138022,0.01423897,0.0009928008],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944935,0.004025804,0.00007937647,0.0003297822,0.0001435659,0.0002618104,0.000305906,0.00004091877,0.0003193352],"genre_scores_gemma":[0.9758514,0.01342062,0.00002101946,0.0002144084,0.000366337,0.0001811092,0.0001620333,0.00003864545,0.009744447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3823017,"threshold_uncertainty_score":0.6363649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01703157921011779,"score_gpt":0.2941804842204493,"score_spread":0.2771489050103315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}