{"id":"W4367047765","doi":"10.1158/2159-8290.cd-22-1013","title":"Splicing Factor SRSF1 Promotes Pancreatitis and KRASG12D-Mediated Pancreatic Cancer","year":2023,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Child Health and Human Development; National Cancer Institute; National Institutes of Health; Zhejiang University; Cold Spring Harbor Laboratory; Hebrew University of Jerusalem; Government of Ontario; Lustgarten Foundation; St. Giles Foundation","keywords":"Pancreatitis; Pancreatic cancer; RNA splicing; Cancer research; Splicing factor; Cancer; Biology; Computational biology; Medicine; Bioinformatics; Genetics; Internal medicine; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001671112,0.0003224925,0.0002616928,0.0002826252,0.0001795939,0.0002544697,0.0001074478,0.0002538702,0.001515253],"category_scores_gemma":[0.0001127884,0.0001544726,0.0003734302,0.0001965101,0.0003143714,0.0001425414,0.000343212,0.0005954851,0.0003913497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002832316,"about_ca_system_score_gemma":0.0002275357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004060401,"about_ca_topic_score_gemma":0.0006542522,"domain_scores_codex":[0.9998189,0.00002729502,0.00002330051,0.0000386986,0.00005095881,0.00004094132],"domain_scores_gemma":[0.9998568,0.00001358805,0.00005805443,0.00001350467,0.00001158941,0.00004640745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002909414,0.00002870347,0.001686822,0.00005108249,0.000009378457,0.0002469887,0.00001623399,0.00004341677,0.9960376,0.00008137626,0.0000876151,0.001419893],"study_design_scores_gemma":[0.00005285739,0.0006308121,0.04246876,0.00001591942,0.00005789491,0.002302795,0.0001077195,0.001276043,0.9472368,0.0001565681,0.00568171,0.00001211928],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994885,0.002137884,0.001384147,0.000185605,0.00003726753,0.0000207767,0.0002837928,0.0001476688,0.0009178757],"genre_scores_gemma":[0.9963045,0.001080783,0.0006501325,0.00006099115,0.00000924044,0.00003093396,0.0004064774,0.00001728635,0.001439658],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001515253,"threshold_uncertainty_score":0.005068958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01703157921011779,"score_gpt":0.2941804842204493,"score_spread":0.2771489050103315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}