{"id":"W4367047968","doi":"10.1128/spectrum.00296-23","title":"Small Molecule Inhibition of an Exopolysaccharide Modification Enzyme is a Viable Strategy To Block Pseudomonas aeruginosa Pel Biofilm Formation","year":2023,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Canadian Glycomics Network; Scheme for Promotion of Academic and Research Collaboration; Hospital for Sick Children; Canadian Institutes of Health Research; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Natural Sciences and Engineering Research Council of Canada; Cystic Fibrosis Canada; Government of Canada","keywords":"Pseudomonas aeruginosa; Biofilm; Microbiology; Enzyme; Pseudomonadaceae; Pseudomonadales; Chemistry; Block (permutation group theory); Bacteria; Biology; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009482714,0.0004602824,0.0002943172,0.0001581405,0.00009865654,0.0002251985,0.0002084756,0.0002698085,0.0008754873],"category_scores_gemma":[0.00009733736,0.0001665344,0.0002123603,0.0001255145,0.0001265751,0.0001217066,0.000170259,0.0004343157,0.0002142717],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001900777,"about_ca_system_score_gemma":0.0001775055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005119762,"about_ca_topic_score_gemma":0.001798453,"domain_scores_codex":[0.999899,0.00001361851,0.000008445771,0.0000208027,0.00003848613,0.00001955737],"domain_scores_gemma":[0.9999526,0.00001185936,0.00001531766,0.000005106295,0.000006759518,0.000008413013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002944362,0.00002418761,0.0000467261,0.00002094553,0.000002878852,0.00001430333,0.000002225989,0.00005798576,0.99876,0.00001916789,0.00001631645,0.001005897],"study_design_scores_gemma":[0.0000143522,0.0005673325,0.001112301,0.000002871861,0.00001088815,0.00008075403,0.000006693534,0.0004792228,0.9968646,0.000009451971,0.000848829,0.000002608555],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896877,0.002238662,0.005447301,0.0001650175,0.00003428253,0.00009592417,0.0004073332,0.0001006393,0.001822982],"genre_scores_gemma":[0.9916285,0.001591707,0.003736602,0.00004743903,0.000005720556,0.00005830822,0.0003937444,0.00001206401,0.002525887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008754873,"threshold_uncertainty_score":0.002928734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02043201926690277,"score_gpt":0.2413741500689287,"score_spread":0.2209421308020259,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}