{"id":"W4367047968","doi":"10.1128/spectrum.00296-23","title":"Small Molecule Inhibition of an Exopolysaccharide Modification Enzyme is a Viable Strategy To Block Pseudomonas aeruginosa Pel Biofilm Formation","year":2023,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Canadian Glycomics Network; Scheme for Promotion of Academic and Research Collaboration; Hospital for Sick Children; Canadian Institutes of Health Research; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Natural Sciences and Engineering Research Council of Canada; Cystic Fibrosis Canada; Government of Canada","keywords":"Pseudomonas aeruginosa; Biofilm; Microbiology; Enzyme; Pseudomonadaceae; Pseudomonadales; Chemistry; Block (permutation group theory); Bacteria; Biology; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002096859,0.0002201714,0.0002278808,0.0001862844,0.0001097366,0.00003057154,0.0001532462,0.0003097467,0.00003150624],"category_scores_gemma":[0.00001858451,0.0002264004,0.00009347511,0.0003090648,0.00007843005,0.00001509932,0.0001103696,0.00009537512,0.0001074544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003015531,"about_ca_system_score_gemma":0.00005976116,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001812592,"about_ca_topic_score_gemma":0.0002107599,"domain_scores_codex":[0.9985524,0.00008540759,0.0003840444,0.000490398,0.00004584124,0.0004419332],"domain_scores_gemma":[0.9992287,0.00000724858,0.0001678788,0.0004201496,0.00007921254,0.00009687757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001154936,0.00005734865,0.00003287538,0.00001887319,0.0000246724,0.000003240823,0.0001141814,0.0001136471,0.9977286,0.0001190114,0.00138864,0.0002834154],"study_design_scores_gemma":[0.0004111282,0.0006859486,0.0003062184,0.00001607861,0.0000176596,0.00007478217,0.0001333499,0.000273282,0.9959091,0.00005840134,0.00186032,0.0002537337],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979162,0.00005451517,0.0003287568,0.0007321232,0.0001688107,0.0003372212,0.0002257116,0.00005813367,0.0001784956],"genre_scores_gemma":[0.9966179,0.00004901402,0.0006669438,0.0004505775,0.0001676788,0.00001521982,0.001734287,0.0000278305,0.0002706102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001819503,"threshold_uncertainty_score":0.9232342,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02043201926690277,"score_gpt":0.2413741500689287,"score_spread":0.2209421308020259,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}