{"id":"W4367048315","doi":"10.1080/09546634.2023.2193663","title":"The clinical relevance of dupilumab serum concentration in patients with atopic dermatitis: a two-center prospective cohort study","year":2023,"lang":"en","type":"article","venue":"Journal of Dermatological Treatment","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"LEO Pharma; Galderma; Sanofi Genzyme; ZonMw; Department of Health and Social Care; National Institute for Health and Care Research; Sanofi; King's College London; Pfizer","keywords":"Dupilumab; Atopic dermatitis; Medicine; Eczema Area and Severity Index; Discontinuation; Adverse effect; Dermatology; Single Center; Internal medicine; Cohort; Clinical trial; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001312991,0.0004608516,0.0005956009,0.0007048674,0.0007101406,0.001038049,0.000547975,0.0007218221,0.002138878],"category_scores_gemma":[0.002098837,0.000448732,0.0008075771,0.0009219557,0.0004608852,0.0006268283,0.0006003386,0.0007699541,0.0003779653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004176533,"about_ca_system_score_gemma":0.0003523014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002856143,"about_ca_topic_score_gemma":0.002295647,"domain_scores_codex":[0.9988438,0.0003092215,0.000101875,0.0004410018,0.0001492394,0.0001548923],"domain_scores_gemma":[0.9980757,0.0003754418,0.0007041958,0.0003027799,0.0001948976,0.0003468585],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004661319,0.00005574489,0.9985055,0.000008747737,0.00008218777,0.00008497447,0.00007076277,0.00001382691,0.0002005845,0.000007321915,0.00003979097,0.0004645224],"study_design_scores_gemma":[0.00004570583,0.0004472027,0.9985311,0.000005318212,0.00008676521,0.0004134009,0.000156147,0.0001221945,0.00006058175,0.00001253903,0.0001125607,0.000006389899],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994018,0.0001530163,0.00007697952,0.00001384251,0.000004372027,0.00001765424,0.0001899077,0.00000199764,0.00014029],"genre_scores_gemma":[0.9994931,0.00005100414,0.00006923998,0.0000173789,0.000007716308,0.00001427905,0.0002660053,0.000001808286,0.00007940402],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002856143,"threshold_uncertainty_score":0.007155299,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02105954719679555,"score_gpt":0.328815252455005,"score_spread":0.3077557052582094,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}