{"id":"W4367050222","doi":"10.1038/s41375-023-01898-w","title":"Ibrutinib sensitizes CLL cells to venetoclax by interrupting TLR9-induced CD40 upregulation and protein translation","year":2023,"lang":"en","type":"article","venue":"Leukemia","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Venetoclax; Ibrutinib; CD40; Cancer research; Chronic lymphocytic leukemia; Bruton's tyrosine kinase; Idelalisib; Medicine; Leukemia; Immunology; Biology; Receptor; Internal medicine; Cytotoxic T cell; Tyrosine kinase; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004878785,0.0002082061,0.0003026835,0.0002176961,0.0001121793,0.00006078276,0.00009108247,0.0001984583,0.0000465691],"category_scores_gemma":[0.0001435372,0.0002032413,0.00006629044,0.0006089415,0.00005290514,0.0001162984,0.00008772238,0.0002622122,0.0003093576],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00886901,"about_ca_system_score_gemma":0.00224736,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007031229,"about_ca_topic_score_gemma":0.00004452594,"domain_scores_codex":[0.9980409,0.00008522817,0.0003629306,0.0004894116,0.0005027514,0.0005187605],"domain_scores_gemma":[0.9990479,0.0001645287,0.00006711432,0.0003558118,0.00008625292,0.000278424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003354635,0.00000920422,0.000045322,0.0002477902,0.00003923589,0.00007487179,0.001808556,0.0003481268,0.9331336,0.00003215996,0.004482702,0.05944299],"study_design_scores_gemma":[0.01182517,0.000488153,0.00144784,0.0007004334,0.00006258214,0.0001025107,0.0004737158,0.2674615,0.7076915,0.0001461706,0.009180737,0.0004197521],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955362,0.00006686651,0.0003037812,0.0007705726,0.0001096845,0.001366247,0.00001227768,0.0002871878,0.001547175],"genre_scores_gemma":[0.9954032,0.00001196749,0.001068074,0.0002245241,0.0002381853,0.00007358223,0.0001113267,0.00005795512,0.002811221],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2671134,"threshold_uncertainty_score":0.9949358,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03847559440720295,"score_gpt":0.3173478667495473,"score_spread":0.2788722723423444,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}