{"id":"W4367054396","doi":"10.3389/fchem.2023.1174363","title":"Amomum subulatum: A treasure trove of anti-cancer compounds targeting TP53 protein using in vitro and in silico techniques","year":2023,"lang":"en","type":"article","venue":"Frontiers in Chemistry","topic":"Ginger and Zingiberaceae research","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"King Saud University","keywords":"Treasure; In silico; In vitro; Computational biology; Biology; Traditional medicine; Chemistry; Biochemistry; Medicine; Philosophy; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001065569,0.000186493,0.0004244301,0.0002662372,0.00005626025,0.0000139899,0.0001895453,0.0003775597,0.00003953225],"category_scores_gemma":[0.0001002971,0.0002058395,0.00004919684,0.000739918,0.0002148549,0.00008711983,0.0001120668,0.001040361,6.029676e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002122222,"about_ca_system_score_gemma":0.0001218082,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001592797,"about_ca_topic_score_gemma":0.0000125982,"domain_scores_codex":[0.9983774,0.0001742714,0.0003997676,0.0003428613,0.0001627621,0.0005429783],"domain_scores_gemma":[0.9995552,0.00009132678,0.00009937707,0.0001245594,0.00004017282,0.00008934252],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002844434,0.0001097838,0.2500658,0.0003883216,0.00002281382,0.00004586251,0.0004322889,0.0001472873,0.745689,3.891647e-7,0.0008020613,0.002011941],"study_design_scores_gemma":[0.001125381,0.000009700183,0.004404366,0.0001408245,0.00001164174,0.00000333048,0.0005079682,0.01572969,0.9768994,0.000148069,0.0008252955,0.0001942746],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969598,0.001720349,0.00001846721,0.0001918611,0.0001201129,0.0003664837,0.00004050352,0.00005083663,0.0005315642],"genre_scores_gemma":[0.9978077,0.0003458608,0.001313564,0.00002868151,0.00007433086,0.00009098405,0.00002603484,0.00002545013,0.0002873649],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2456614,"threshold_uncertainty_score":0.8393893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07515673143347687,"score_gpt":0.4234990509776499,"score_spread":0.3483423195441731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}