{"id":"W4367059179","doi":"10.1101/2023.04.25.23289108","title":"Differences in AD-related pathology profiles across APOE groups","year":2023,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Douglas Mental Health University Institute; McGill University; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; Alzheimer Society Research Program; Alzheimer Society; Fondation Brain Canada; Alzheimer's Disease Neuroimaging Initiative","keywords":"Apolipoprotein E; Psychology; Pathology; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001605265,0.0004828493,0.0003782162,0.001116378,0.0003342907,0.0006036476,0.0003432489,0.0004961099,0.002660732],"category_scores_gemma":[0.002895481,0.0001578901,0.0004576757,0.0004852691,0.0003072951,0.0004389907,0.0004251176,0.0001996867,0.0004355124],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002130293,"about_ca_system_score_gemma":0.0001834169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001505957,"about_ca_topic_score_gemma":0.001909046,"domain_scores_codex":[0.9994227,0.0001344747,0.00007806093,0.0001736459,0.0001019725,0.00008920401],"domain_scores_gemma":[0.99888,0.0003607868,0.0003485602,0.0001295858,0.0001546072,0.0001265084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004977664,0.0002404976,0.9758623,0.0000398616,0.0005130355,0.0002833345,0.0006365071,0.0001352769,0.009276195,0.0002692438,0.0002111933,0.007554976],"study_design_scores_gemma":[0.00003027677,0.0003734,0.9975554,0.000008828502,0.00007071561,0.000331138,0.0002643066,0.0002096747,0.0004993125,0.0004490108,0.000200635,0.000007230147],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998772,0.0001210078,0.0002289002,0.00001565074,0.000002670393,0.00002337232,0.0002869395,0.000008410994,0.0005411276],"genre_scores_gemma":[0.9989208,0.00003189945,0.0002351532,0.00001489748,0.000003012908,0.00002684352,0.0003614386,0.000006037968,0.0003999825],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002660732,"threshold_uncertainty_score":0.008901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05588170077666489,"score_gpt":0.3581098325019182,"score_spread":0.3022281317252533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}