{"id":"W4367059606","doi":"10.1126/sciadv.ade0631","title":"Abrogation of MAP4K4 protein function causes congenital anomalies in humans and zebrafish","year":2023,"lang":"en","type":"article","venue":"Science Advances","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre; McMaster University; Trillium Health Centre","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Child Health and Human Development; National Institute of Mental Health; National Institute of General Medical Sciences; National Center for Advancing Translational Sciences; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Human Genome Research Institute","keywords":"Zebrafish; Biology; Kinase; Protein kinase A; Genetics; Signal transduction; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001602361,0.0009775683,0.0003701859,0.0008625297,0.0004178855,0.0002372549,0.0003785119,0.0005228349,0.002500776],"category_scores_gemma":[0.0003155133,0.0002919406,0.0004750322,0.0003125437,0.0009661921,0.0001647698,0.0006790688,0.0004105,0.0002435424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006425012,"about_ca_system_score_gemma":0.0005397015,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003557472,"about_ca_topic_score_gemma":0.00539836,"domain_scores_codex":[0.9996897,0.00003709127,0.00002991148,0.00009618358,0.00009857322,0.00004858942],"domain_scores_gemma":[0.9998635,0.00002902712,0.00005985005,0.00001410665,0.000007061343,0.00002652049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004441675,0.00004491103,0.007435062,0.0001080583,0.0001265012,0.008742716,0.0001417949,0.0008401106,0.9719991,0.00115438,0.0003203227,0.008642813],"study_design_scores_gemma":[0.0002165554,0.001382621,0.1946076,0.00009054971,0.0006637037,0.07508545,0.0003776885,0.004188387,0.7045937,0.00149115,0.01715193,0.0001507128],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953167,0.000613577,0.002210608,0.0001118783,0.00001567581,0.0000262414,0.0004428976,0.0001076698,0.001154704],"genre_scores_gemma":[0.9951543,0.0005722201,0.002432601,0.00004419011,0.00000636798,0.00003011478,0.0002937474,0.00003782715,0.001428528],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003557472,"threshold_uncertainty_score":0.008365929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01089686155900394,"score_gpt":0.2549691599821191,"score_spread":0.2440722984231151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}