{"id":"W4367173598","doi":"10.1021/acschembio.3c00066","title":"SARS-CoV-2 Spike N-Terminal Domain Engages 9- <i>O</i> -Acetylated α2–8-Linked Sialic Acids","year":2023,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"H2020 European Research Council; National Institute of General Medical Sciences; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Bill and Melinda Gates Foundation; Koninklijke Nederlandse Akademie van Wetenschappen; National Heart, Lung, and Blood Institute; Instituto de Salud Carlos III","keywords":"Glycan; Sialic acid; Receptor; Binding domain; Binding site; Amino acid; Acetylation; Plasma protein binding; Biochemistry; Biology; Chemistry; Glycoprotein; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000622995,0.0003391653,0.0006713683,0.0002515426,0.0001101291,0.00002550575,0.0004467539,0.0007120997,0.00002606357],"category_scores_gemma":[0.0007921039,0.0002794347,0.0002141646,0.0009644222,0.0005792256,0.00005477618,0.0003669753,0.0009555886,0.001383932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001134467,"about_ca_system_score_gemma":0.0001967371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006488817,"about_ca_topic_score_gemma":0.000005132659,"domain_scores_codex":[0.9973162,0.0001757602,0.0004858515,0.0007327858,0.0002875107,0.001001928],"domain_scores_gemma":[0.9986256,0.000461341,0.00008342212,0.0006195472,0.0001267958,0.00008333746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005019419,0.0001197355,0.006155368,0.00007157644,0.00009771191,0.0004225768,0.0001640279,8.942179e-9,0.9833996,0.0002672408,0.004252537,0.004547643],"study_design_scores_gemma":[0.001973479,0.0002931475,0.0003405049,0.00003176344,0.00003531013,0.0001807749,0.00005560835,0.00002369455,0.7788398,0.00112201,0.2168725,0.0002314583],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938332,0.0002305135,0.00002296732,0.002284513,0.0002395429,0.0004057455,0.00002931035,0.0005103551,0.002443779],"genre_scores_gemma":[0.9646032,0.00003072446,0.0002171572,0.0341992,0.0005749469,0.0000955228,0.00015501,0.00005393738,0.00007028886],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2126199,"threshold_uncertainty_score":0.9999658,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0568852919581263,"score_gpt":0.3707883401953734,"score_spread":0.3139030482372471,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}