{"id":"W4367173598","doi":"10.1021/acschembio.3c00066","title":"SARS-CoV-2 Spike N-Terminal Domain Engages 9- <i>O</i> -Acetylated α2–8-Linked Sialic Acids","year":2023,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"H2020 European Research Council; National Institute of General Medical Sciences; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Bill and Melinda Gates Foundation; Koninklijke Nederlandse Akademie van Wetenschappen; National Heart, Lung, and Blood Institute; Instituto de Salud Carlos III","keywords":"Glycan; Sialic acid; Receptor; Binding domain; Binding site; Amino acid; Acetylation; Plasma protein binding; Biochemistry; Biology; Chemistry; Glycoprotein; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000988528,0.0003554022,0.0001345997,0.0002181734,0.0001245162,0.0002841723,0.0002605755,0.0003567359,0.00746592],"category_scores_gemma":[0.0001015324,0.0001832652,0.0001803041,0.0001595605,0.0001425397,0.0003472089,0.0002178134,0.000403596,0.00162588],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001900067,"about_ca_system_score_gemma":0.0001241084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004974275,"about_ca_topic_score_gemma":0.0007481845,"domain_scores_codex":[0.9999232,0.000004165214,0.00000269702,0.0000251167,0.00002825312,0.00001643253],"domain_scores_gemma":[0.9999548,0.00001064846,0.000009217457,0.000005703014,0.00001039392,0.000009302615],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006116745,0.000007617172,0.0001618148,0.00003195248,0.000002889592,0.00005063769,0.000008709161,0.00003087657,0.9978218,0.00009049098,0.0003354013,0.00139674],"study_design_scores_gemma":[0.00000912743,0.00009099786,0.004478673,0.000006574009,0.00000545743,0.0003072693,0.00004226514,0.002000129,0.9888462,0.00007534404,0.004130096,0.000007924075],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9516531,0.0008652158,0.02487466,0.0004287618,0.0001150613,0.00007519161,0.004358036,0.001334028,0.01629595],"genre_scores_gemma":[0.9250831,0.001699252,0.03953976,0.0003644715,0.00004539289,0.0001412822,0.007162401,0.0002426422,0.0257217],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00746592,"threshold_uncertainty_score":0.02497602,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0568852919581263,"score_gpt":0.3707883401953734,"score_spread":0.3139030482372471,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}