{"id":"W4367176978","doi":"10.1038/s41556-023-01130-y","title":"Stomach-derived human insulin-secreting organoids restore glucose homeostasis","year":2023,"lang":"en","type":"article","venue":"Nature Cell Biology","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; U.S. Department of Health and Human Services","keywords":"PDX1; Organoid; Stem cell; Glucose homeostasis; Biology; Enteroendocrine cell; Insulin; Cell biology; Homeostasis; Islet; Transplantation; Regeneration (biology); Internal medicine; Endocrinology; Medicine; Endocrine system; Insulin resistance; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002579744,0.0001948621,0.0003857297,0.000276376,0.0001570088,0.000009966568,0.0001177907,0.0007500272,0.0005991745],"category_scores_gemma":[0.0005625159,0.0001567208,0.0001015655,0.0006365147,0.0001285328,0.00002445265,0.00008208793,0.0007528938,0.0004685494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006236863,"about_ca_system_score_gemma":0.00007627634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001682307,"about_ca_topic_score_gemma":0.000004005733,"domain_scores_codex":[0.9987354,0.00009742449,0.0002426881,0.0003937751,0.0001260399,0.0004047306],"domain_scores_gemma":[0.9990602,0.0002136273,0.00009100207,0.0003469592,0.0001209915,0.0001672113],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009493911,0.00005806722,0.0218025,0.00007972015,0.00004900039,0.00004939163,0.0001571418,6.86729e-7,0.9622733,0.0002987568,0.01112009,0.004016373],"study_design_scores_gemma":[0.003910986,0.0009004127,0.1068498,0.0000734331,0.0001509132,0.00001766203,0.0005399304,0.00009744825,0.7127528,0.0005369079,0.1737781,0.0003915311],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9774703,0.005855698,0.000005331053,0.0008212269,0.000687126,0.0002129968,0.0000219683,0.0004566496,0.01446866],"genre_scores_gemma":[0.9944162,0.000450348,0.0002582381,0.001937076,0.0004555606,0.00001631191,0.0006150792,0.00003342304,0.001817801],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2495205,"threshold_uncertainty_score":0.656054,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01496122816289513,"score_gpt":0.2899545290935718,"score_spread":0.2749933009306767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}