{"id":"W4367293587","doi":"10.1016/j.biopsych.2023.04.019","title":"The p75 Neurotrophin Receptor in Preadolescent Prefrontal Parvalbumin Interneurons Promotes Cognitive Flexibility in Adult Mice","year":2023,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Nerve injury and regeneration","field":"Neuroscience","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Centre hospitalier universitaire Sainte-Justine","keywords":"Parvalbumin; Prefrontal cortex; Neuroscience; Cognitive flexibility; Conditional gene knockout; Interneuron; Knockout mouse; Biology; Psychology; Receptor; Phenotype; Cognition; Inhibitory postsynaptic potential","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003798,0.0001951886,0.0001746168,0.00007316151,0.0001592447,0.0000501763,0.0003550971,0.0001488364,0.00001909193],"category_scores_gemma":[0.00141393,0.0001155823,0.00008863834,0.0005288697,0.0003086183,0.00009331366,0.0001556539,0.00046163,0.000209237],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000416837,"about_ca_system_score_gemma":0.00004821579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003189702,"about_ca_topic_score_gemma":0.0004441543,"domain_scores_codex":[0.9973652,0.0008972634,0.0004314511,0.0007202057,0.0001624592,0.0004234582],"domain_scores_gemma":[0.9991924,0.0004021167,0.0000989293,0.0002125449,0.00002472034,0.00006935047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002074527,0.001698269,0.2246712,0.00005900932,0.00000602552,0.00003609404,0.0003833998,0.00004272323,0.7542289,0.005873499,0.002033658,0.008892648],"study_design_scores_gemma":[0.00168878,0.00140821,0.8329526,0.000276039,0.00000684714,0.00001616343,0.0004690714,0.001895823,0.1547817,0.005263593,0.000693094,0.0005481259],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937165,0.00006189009,0.000009752207,0.003351009,0.001605138,0.0008460149,0.0000530687,0.0001365565,0.0002201162],"genre_scores_gemma":[0.9985154,0.0001435324,0.0000400826,0.0007353037,0.0001860541,0.0001287575,0.00001793766,0.00001188257,0.0002210429],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6082813,"threshold_uncertainty_score":0.4713308,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06334634068691432,"score_gpt":0.3167094157705584,"score_spread":0.2533630750836441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}