{"id":"W4367296219","doi":"10.1212/wnl.0000000000202257","title":"Phase 3, Open-Label, Multicenter Safety Study of Oral Edaravone in Patients With Amyotrophic Lateral Sclerosis (MT-1186-A01): 48-Week Results (P6-4.001)","year":2023,"lang":"en","type":"article","venue":"Neurology","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"","keywords":"Tolerability; Medicine; Dysphagia; Adverse effect; Edaravone; Amyotrophic lateral sclerosis; Constipation; Anesthesia; Internal medicine; Surgery; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002467406,0.001548471,0.001723406,0.0003405878,0.000696464,0.0009689794,0.0009821824,0.001632261,0.005967],"category_scores_gemma":[0.001155567,0.0005220544,0.001730594,0.0003388129,0.0007062757,0.0007523245,0.0003743682,0.003103154,0.001284247],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007466645,"about_ca_system_score_gemma":0.001895048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009750996,"about_ca_topic_score_gemma":0.002458436,"domain_scores_codex":[0.9995016,0.0002134915,0.00002773843,0.00009300931,0.00008554261,0.00007855867],"domain_scores_gemma":[0.9989671,0.0001365042,0.0002691496,0.0000900046,0.0001631939,0.0003742068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7626987,0.06843479,0.01004668,0.00115237,0.002397716,0.0003303146,0.0003722301,0.001153239,0.06225514,0.000214608,0.01331538,0.07762895],"study_design_scores_gemma":[0.6439884,0.3195007,0.02512854,0.00005178575,0.000677186,0.0003979477,0.00007472575,0.0007921898,0.004916377,0.0002026872,0.004224482,0.00004487264],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848294,0.001818525,0.00101825,0.0005202522,0.000159849,0.00494506,0.004248693,0.0002471246,0.002212931],"genre_scores_gemma":[0.9762591,0.001207685,0.003533654,0.001939434,0.0002744356,0.006126584,0.007027452,0.00009538913,0.003536344],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005967,"threshold_uncertainty_score":0.0199616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07865554970075926,"score_gpt":0.3424870116165921,"score_spread":0.2638314619158328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}