{"id":"W4367296309","doi":"10.1212/wnl.0000000000204094","title":"Protection against toxic amyloid-beta oligomers by PMN310, a monoclonal antibody rationally designed for greater therapeutic potency in Alzheimer’s disease (P1-6.006)","year":2023,"lang":"en","type":"article","venue":"Neurology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Amorfix (Canada)","funders":"","keywords":"In vivo; Monoclonal antibody; Toxicity; Antibody; In vitro; Potency; Epitope; Thioflavin; Pharmacology; Amyloid (mycology); Chemistry; Amyloid beta; Alzheimer's disease; Peptide; Biochemistry; Molecular biology; Biology; Immunology; Pathology; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000281635,0.0003092212,0.0002083379,0.0001574791,0.0001240734,0.0001437456,0.0001755464,0.0003683785,0.001082971],"category_scores_gemma":[0.0001606017,0.0001146272,0.0001551179,0.00008808795,0.0001619661,0.0002954553,0.00009434604,0.000471552,0.000252596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001813641,"about_ca_system_score_gemma":0.0002390989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005288094,"about_ca_topic_score_gemma":0.0003689801,"domain_scores_codex":[0.9999171,0.00001583819,0.000007038606,0.00001182359,0.00001974647,0.00002835571],"domain_scores_gemma":[0.9999492,0.00001156792,0.00001131514,0.000003452998,0.000009867674,0.00001459163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007059171,0.0003431495,0.0002979247,0.00004236922,0.000008821966,0.00007391177,0.00002122389,0.0002871693,0.9933832,0.0001512658,0.0001127219,0.004572328],"study_design_scores_gemma":[0.0002749984,0.005526473,0.002466984,0.000005613825,0.00002300442,0.0004393984,0.00001266307,0.001453359,0.9884991,0.00008797871,0.001205412,0.000004999072],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972384,0.0005668877,0.000978093,0.00007522482,0.00001960838,0.00004129129,0.00007581026,0.00002430278,0.0009803852],"genre_scores_gemma":[0.9967945,0.0004455787,0.001602907,0.000046319,0.000006775085,0.0000229123,0.0001439134,0.0000046742,0.0009323574],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001082971,"threshold_uncertainty_score":0.00362283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04891063510883852,"score_gpt":0.3283391436329852,"score_spread":0.2794285085241466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}